Unit:
Κατεύθυνση Εργαστηριακή / Βασική ΈρευναLibrary of the School of Health Sciences
Author:
Zemadanis Konstantinos
Supervisors info:
Μιχαήλ Κουτσιλιέρης, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ, Επιβλέπων
Αναστάσιος Φιλίππου, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Αντώνιος Χατζηγεωργίου, Επίκουρος Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Η επίδραση τεχνικών Χειροθεραπείας (Manual Therapy) στην κλινική εικόνα και στα επίπεδα της IL-1β σε ασθενείς με χρόνιο αυχενικό μηχανικό πόνο
Translated title:
The effect of Manual Therapy techniques on clinical status and IL-1b levels in patients with chronic mechanical neck pain
Summary:
INTRODUCTION: Chronic cervical mechanical pain is a common musculoskeletal dysfunction and Manual Therapy is one of the treatment modalities with evidence of improvement in symptoms, but the effect on dosage, type of intervention, and underlying mechanisms of action are unclear. The aim of the study was to investigate the acute and short-term effect of cervical spine mobilization/manipulations on patient’s pain and functionality. In addition, to investigate the underlying mechanism of action by detecting changes in the concentration of inflammatory biomarkers, such as interleukin-1b.
METHODS: Twenty-two (n = 22) patients aged 20-50 years with a clinical status of chronic mechanical pain (> 3 months) in the cervical spine, consisted of the study sample, randomly assigned and classified into two equal groups. The study group, which received nine sessions of a three-week Manual Therapy intervention, and the control group receiving SHAM Manual Therapy of the same dosage. In addition, blood samples were collected through blood sampling in order to analyze IL-1β concentrations.
MEASURES: Pain and functionality were the dependent variables measured before and after intervention with the NPRS (ICC = 0.76) and NDI (ICC = 0.86) scales, respectively. IL-1β was additionally measured after the first session using the corresponding kit (ELISA). Statistical analysis was conducted with SP Mixed ANOVA detecting for differences in the dependent variables on the two levels of the independent variable (GROUP / TIME), at the significance level a = .05.
RESULTS: There was a significant statistical interaction and significant main effects on the dependent variables of pain, functionality, IL-1β (p <.05) for the independent variable levels between groups (GROUP) and measurements (TIME). The decrease in IL-1β concentration was statistically significant (p <.05) between the first and second measurement, on the study group, but not significant (p> .05) between the second and final measurements. No statistical significance was found for the control group on any of the dependent variables across measurements.
CONCLUSION: Patients with chronic mechanical pain in the cervical spine showed a significant improvement in their clinical status in terms of pain and functionality after applying manual therapy specific techniques compared to a control group. The underlying mechanism of action is probably linked to the reduced activation of inflammatory-cytokine signaling molecules (e.g. IL-1β), directing future research efforts on molecular-level profile of patients.
Main subject category:
Health Sciences
Keywords:
Manual therapy, Neck pain, IL-1b
