Unit:
Κατεύθυνση Έρευνα στην Γυναικεία ΑναπαραγωγήLibrary of the School of Health Sciences
Author:
Papargyri Panagiota
Supervisors info:
Γεώργιος Μαστοράκος, Καθηγητής, Τμήμα Ιατρικής, ΕΚΠΑ, Επιβλέπων
Νικόλαος Σαλάκος, Καθηγητής, Τμήμα Ιατρικής, ΕΚΠΑ
Αλεξάνδρα Μπαργιώτα, Επίκουρη Καθηγήτρια, Τμήμα Ιατρικής, Πανεπιστήμιο Θεσσαλίας
Original Title:
Links between HPA axis and adipokines
Translated title:
Links between HPA axis and adipokines
Summary:
Introduction: In the human organism, a constant interplay exists between the stress system [which includes the activity of the hypothalamic-pituitary-adrenal (HPA) axis] and the adipose tissue. This interplay is mediated by hormones of the HPA axis such as corticotropin-releasing-hormone (CRH), adrenocorticotropic hormone (ACTH) and glucocorticoids (GCs) and adipokines secreted by the adipose tissue.
Areas covered: In this critical review, the bi-directional interactions between HPA axis and the most studied adipokines such as leptin and adiponectin, as well as the pro-inflammatory adipocytokines tumor necrosis factor (TNF) and interleukin (IL) 6 are presented. Furthermore, these interactions are described in normalcy as well as in specific clinical paradigms of stress-related disorders such as eating disorders, hypothalamic amenorrhea and sress-related endogenous hypercortisolism states. Wherever new therapeutic strategies emerge, they are presented accordingly.
Expert commentary: Additional research is needed in order to clarify the mechanisms involved in the interplay between the HPA axis and the adipose tissue. Research should be focused, in particular, on the development of new therapeutic means targeting dysfunctional adipose tissue in stress-related situations.
Main subject category:
Health Sciences
Keywords:
Adipokines, Adiponectin, Cortisol, Eating disorders, HPA axis, Hypothalamic amenorrhea, IL-6, Leptin, Stress, TNF
Number of references:
196
