Unit:
Κατεύθυνση Παιδιατρική ΛοιμωξιολογίαLibrary of the School of Health Sciences
Supervisors info:
Νικόλαος Σπυρίδης, Επίκουρος Καθηγητής,Ιατρική Σχολή, ΕΚΠΑ, Επιβλέπων
Αθανάσιος Μίχος, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Σουλτάνα Σιαχανίδου, Αναπληρώτρια Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Μελέτη καταγραφής της συσχέτισης της βακτηριακής χλωρίδας και εμπειρικής αντιβιοτικής αγωγής σε ογκολογικούς ασθενείς με επιβεβαιωμένη βακτηριαιμία
Translated title:
A study of the accociation between gut flora and empirical antibiotic therapy in oncology patients with confirmed bloodstream infection.
Summary:
Infections are an important research area in the field of Pediatric Hematology - Oncology. Children who suffer from cancer present an increased risk for infections and respective complications, such as septicemia. With the aim of early diagnosis and accurate treatment, it is crucial the intestinal colonization of patients be regularly monitored. Based on the intestinal colonization, the empirical antibiotic treatment is adjusted.
The objective of the present study is to examine the association between surveillance cultures and empirical antibiotic treatment in children with cancer and confirmed bloodstream infection in two pediatric oncology departments, P&A KYRIAKOU and MITERA, from January 2015 to February 2018 and from February 2014 and December 2018, respectively. A total number of 129 bloodstream infections were recorded in 84 patients with cancer, in 97 incidents of which the colonization data were prior to bloodstream infection.
Intestinal colonization by MDR pathogens was found to be statistically correlated with the presence of bloodstream infection derived from multidrug-resistant bacteria, as well as, that the shorter time between surveillance culture and blood culture was in a significant way correlated with the detection of identical pathogen. In 22 cases was found an identical pathogen to that of the advanced intestinal flora colonization culture. In most cases, the empirical antibiotic treatment was found to be appropriate based on the antibiogram of the blood culture, however, in a percentage of 52% the treatment was modified according to the patient's clinical picture.
Main subject category:
Health Sciences
Keywords:
Child, Cancer, Bloodstream infection, Surveillance cultures, Empirical antibiotic therapy
