Κατεύθυνση Αναπαραγωγική-Αναγεννητική ΙατρικήLibrary of the School of Health Sciences
Πέτρος Δρακάκης, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Αικατερίνη Ντόμαλη, Επίκουρη Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Δέσποινα Μαυρογιάννη, ΕΔΙΠ, Ιατρική Σχολή, ΕΚΠΑ
Η ανίχνευση miRNAs σε γυναίκες με υπογονιμότητα. Μελέτη let-7c γονιδίου σε γυναικείο υπογόνιμο πληθυσμό.
MiRNAs detection among women with subfertility. Let-7c gene study in female subfertile population.
It is generally admitted that miRNAs possess the scientist’s interest during the last years in the field of infertility. This fact does not seem absurd at all, considering their capability they seem to have either as biomarkers or as therapeutic targets. These small, non-coding RNA molecules are abundant in many types of mammal cells and seem to target approximately 60% of human and other mammals genes. Their application in cancer, Polycystic Ovary Syndrome (POS) and Endometriosis are only a few examples, which justify the persistence of the scientific community for further investigation in subfertile and non-subfertile population. One of the most important miRNAs is the let-7 family, as they constitute an attractive, possibly therapeutic way to prevent tumorigenesis usually in cancers which underexpress the let-7 gene. The «newborn» gene let-7 was initially discovered in the nematode C. elegans as the main development regulator and constituted, along with the lin-4 gene, two of the most known microRNAs. The applications of the let-7 family genes are identified also in the assisted reproduction field, in which attempts are taking place in order to find correlation between the gene and the oocytes. The main target that was set in this particular paper is the study of the let-7c gene of the let-7 miRNAs’ family among women, who underwent Assisted Reproduction methods and whichever correlation of this gene with subfertility. By using molecular methods on cumulus cells, a low expression pattern of the le-7c gene was observed, among women who came to be undergone at Assisted Reproductive Technology methods.
Main subject category:
Gene study, miRNAs, let-7c, Subfertility, Assisted reproduction