Unit:
Κατεύθυνση Αλγολογία: Αντιμετώπιση του πόνου, διάγνωση και θεραπεία. Φαρμακευτικές, παρεμβατικές και άλλες τεχνικέςLibrary of the School of Health Sciences
Author:
Kyriakidis Vasileios
Supervisors info:
Αικατερίνη Αμανίτη, Αναπληρώτρια Καθηγήτρια, Τμήμα Ιατρικής, ΑΠΘ, Επιβλέπουσα
Εριφύλη Αργύρα, Καθηγήτρια, Τμήμα Ιατρικής, ΕΚΠΑ
Κασσιανή Θεοδωράκη, Αναπληρώτρια Καθηγήτρια, Τμήμα Ιατρικής, ΕΚΠΑ
Original Title:
O ρόλος των συνοδών φαρμάκων (δεξαμεθαζόνη, δεξμεδετομιδίνη) στους περιφερικούς νευρικούς αποκλεισμούς για μετεγχειρητική αναλγησία. Κλινική μελέτη.
Translated title:
The role of adjuvants (dexamethasone, dexmedetomidine) on peripheral nerve blocks for postoperative analgesia. Clinical Trial.
Summary:
Postoperative analgesia is a major goal of anesthesiologist, in the frame of perioperative management of patients. Regional anesthesia, as a component of postoperative analgesia, provides safe, lasting and effective analgesia, as it is proven through evidence-based knowledge and experience of many decades of practice of central and peripheral nerve blocks.
Towards this direction, substances that modify or supplement the effects of local anesthetics, are co-administered. Dexamethasone and dexmedetomidine are remarkably interesting adjuvants, since they seem to reliably prolong the duration of analgesia, and despite their side effects, render regional anesthesia safer and more effective.
In the current clinical trial the adjuvants dexmedetomidine and dexamethasone were studied, alongside with ropivacaine, for interscalene brachial plexus block, by comparing, on a three-branch study, dexmedetomidine or dexamethasone or the combination of two. Statistical significance was not achieved, probably because of the small study sample. Nevertheless, the combination of two adjuvants seems superior regarding the duration of analgesia, with no adverse effects.
Main subject category:
Health Sciences
Keywords:
Adjuvants, Dexamethasone, Dexmedetomidine, Peripheral nerve blocks
