Survival from biliary tract cancer and increased body weight: a systematic review and meta-analysis

Postgraduate Thesis uoadl:2897501 55 Read counter

Κατεύθυνση Σχεδιασμός και Διοίκηση Υπηρεσιών Υγείας
Library of the School of Health Sciences
Deposit date:
Katsari Vasiliki
Supervisors info:
Παύλος Σαράφης, Επίκουρος Καθηγητής, Τμήμα Νοσηλευτικής, Σχολή Επιστημών Υγείας, Τεχνολογικό Πανεπιστημίου Κύπρου
Ιωάννης Τούντας, Καθηγητής, Ιατρική Σχολή, Εθνικό Καποδιστριακό Πανεπιστήμιο Αθηνών
Μαρία Καντζανού, Επίκουρη Καθηγήτρια, Ιατρική Σχολή Αθηνών, Εθνικό Καποδιστριακό Πανεπιστήμιο Αθηνών
Original Title:
Επιβίωση από χολαγγειοκαρκίνωμα και αυξημένο σωματικό βάρος: Συστηματική ανασκόπηση και μετα-ανάλυση προοπτικών μελετών
Translated title:
Survival from biliary tract cancer and increased body weight: a systematic review and meta-analysis
The role of overweight and obesity on the prognosis of biliary tract cancer (BTC) remains unclear. This systematic review and meta-analysis aims to examine the association between being overweight/obesity and BTC prognosis (overall survival, progression-free survival and response rates). Potentially eligible publications were sought in PubMed up to December 31, 2019. Random-effects meta-analysis was conducted to combine estimates; Cochran Q and I2 statistic and were used for the assessment of between-study heterogeneity. Five observational studies including a total of 1,160 tumor patients were included in the qualitative synthesis, among which three studies were retained for the meta-analysis, involving 1,060 cancer cases. No statistically significant association was found between overweight/obesity and the overall survival of BTC [pooled hazard ratios (HR)=1.07; 95% confidence interval (95% CI): 0.85-1.35, seven study arms]. Notably, in a subgroup analysis, obese subjects showed decreased overall survival [pooled HR=1.57; 95% CI: 1.03-2.40, two study arms] versus normal weight patients. In conclusion, there is suggestive evidence that obesity may contribute to poorer prognosis of biliary cancer, in comparison to normal weight status. Additional studies from various geographic regions are needed to further substantiate and validate the present findings.
Main subject category:
Health Sciences
Obesity, Biliary Tract Cancer, Cholangiocarcinoma, Survival, Meta-analysis
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