The impact of gentamicin administration in children’s hearing ability

Postgraduate Thesis uoadl:2897873 226 Read counter

Unit:
Κατεύθυνση Ακοολογία–Νευροωτολογία
Library of the School of Health Sciences
Deposit date:
2020-02-21
Year:
2020
Author:
Panagiotidis Alexandros
Supervisors info:
Αθανάσιος Μπίµπας, Αναπληρωτής Καθηγητης, Τμήμα Ιατρικής, ΕΚΠΑ
Ιωάννης Σέγγας, Καθηγητής, Τμήμα Ιατρικής, ΕΚΠΑ
Ευθύμιος Κυροδήμος, Επίκουρος Καθηγητής, Τμήμα Ιατρικής, ΕΚΠΑ
Original Title:
Η επίδραση της χορήγησης γενταμικίνης στην ακοή σε παιδιά
Languages:
Greek
Translated title:
The impact of gentamicin administration in children’s hearing ability
Summary:
Introduction: In order to proceed to a successful detection of ototoxicity, in the pediatric population, you will require the use of audiological tests capable to detect the early onset of ototoxicity. The main goal is to be able to detect, primarily, transitions of hearing thresholds to high frequencies. Based on the literature (see bibliography at the end), the most validated examinations are the Distortion Products Otoacoustic Emissions (DPOAEs) and the High Frequency Audiometry (HFA). The purpose of this review is to investigate the literature on the effects of Gentamicin on hearing in children.
Material and Method: A review on the existing English-language articles from 1995 to September 2019 in the PubMed and Cochrane databases using appropriate terms.
Results: Following a systematic research and study of existing arthrographic cases, three articles were selected that concerned the detection of ototoxicity in a pediatric population previously treated with Gentamicin. Two out of the three studies, used PTA and OAEs to detect ototoxicity while one study used BAER, HFA, and PTA.
Discussion: Two of the three studies identified low rates of ototoxicity. One out of the three was unable to detect ototoxicity, based on the ototoxicity criteria that were set. However, the DPOAEs and TEOAEs tests showed significant changes in the respective variables.
Conclusions: Ototoxicity, deriving from Gentamicin in the outer cochlea, appears to be insufficiently illustrated by existing arthrography. The application of protocols and guidelines capable to detect the early installation of ototoxicity is more than necessary. Gentamicin’s effect on the outer scalp-based hair cells may affect the perception of high frequencies, which play a crucial role in speech discrimination, especially in environments with increased levels of noise.
Main subject category:
Health Sciences
Keywords:
Gentamicin, Ototoxicity, Children, Hearing Loss, Aminoglycosides, Audio Visual Emissions, High Frequency Tone Audiogram
Index:
No
Number of index pages:
0
Contains images:
No
Number of references:
47
Number of pages:
45
File:
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