Supervisors info:
Ευθυμιάδου Ελένη, Επίκουρος Καθηγήτρια Ανόργανης Χημείας, Τμήμα Χημείας, Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθήνας
Original Title:
ΘΕΡΑΝΩΣΤΙΚΕΣ ΕΦΑΡΜΟΓΕΣ ΝΑΝΟΣΩΜΑΤΙΔΙΩΝ ΤΟΥ ΧΡΥΣΟΥ, ΤΡΟΠΟΠΟΙΗΜΕΝΩΝ ΜΕ ΑΝΑΣΤΟΛΕΙΣ ΤΗΣ ΑΓΓΕΙΟΓΕΝΕΣΗΣ, ΣΤΟΝ ΚΑΡΚΙΝΟ ΤΟΥ ΓΛΟΙΟΒΛΑΣΤΩΜΑΤΟΣ
Translated title:
THERANOSTIC APPLICATIONS OF GOLD NANOPARTICLES, MODIFIED WITH INHIBITORS OF ANGIOGENESIS, IN GLIOBLASTOMA' S CANCER
Summary:
The purpose of this thesis is the design, synthesis, characterisation and biological evaluation of drugs and Nano-drug delivery systems, to target the cancerous angiogenesis.
The presented Nano-systems consist of spherical gold nanoparticles coated with citric acid in order to have good colloidal solutions. Taking advantage of the citric acid, the gold nanoparticles are coated with platinum nanoparticles to cause oxidative stress to the cells which are near the targeted region, in order to enhance the anticancer activity. Furthermore, a small organic molecule is synthesized, through which, energetic targeting of an angiogenesis factor, the Vascular Endothelial Growth Factor will probably be succeeded, inhibiting its expression and thus the angiogenesis. The small organic molecule synthesized is a quinazoline derivative, since quinazoline is widely known for its anti-inflammatory activity. The small organic molecule will also be conjugated to the gold nanoparticles.
These Drug Delivery Systems (DDS) are tested in glioblastoma cell lines, U87MG, D54 that are angiogenetic-dependent cancer cell lines and the U251 which is not VEGFR-dependent, as well as the HEK293 cell line, which is healthy embryonic cells of liver. The DDS can be used as imaging agents due to the optical properties of the gold, which are enhanced when the gold nanoparticles are coated with the platinum nanoparticles.
Keywords:
Nanoparticles, Gold, Platinum, Angiogenesis, Glioblastoma
