The prognostic significance and immuno-expression of survivin and its correlation with other apoptotic factors in epithelial ovarian cancer

Doctoral Dissertation uoadl:2898821 74 Read counter

Unit:
Τομέας Υγείας - Μητέρας - Παιδιού
Library of the School of Health Sciences
Deposit date:
2020-03-06
Year:
2020
Author:
Chados Nikolaos
Dissertation committee:
1. Οδυσσέας Γρηγορίου, Ομότιμος Καθηγητής, Ιατρικής, ΕΚΠΑ
2. Ευθύμιος Δεληγεώρογλου, Ομότιμος Καθηγητής, Ιατρικής, ΕΚΠΑ
3. Νικόλαος Σαλάκος, Καθηγητής, ΕΚΠΑ
4. Κωνσταντίνος Πανουλής, Αναπληρωτής Καθηγητής, ΕΚΠΑ
5. Καλλιόπη Παππά, Αναπληρώτρια Καθηγήτρια, ΕΚΠΑ
6. Λέων Αραβαντινός, Επίκουρος Καθηγητής, ΕΚΠΑ
7. Περικλής Παναγόπουλος, Επίκουρος Καθηγητής, ΕΚΠΑ
Original Title:
Η προγνωστική σημασία της έκφρασης της SURVIVIN και ο συσχετισμός της με άλλους αποπτωτικούς παράγοντες στον επιθηλιακό καρκίνο των ωοθηκών
Languages:
Greek
Translated title:
The prognostic significance and immuno-expression of survivin and its correlation with other apoptotic factors in epithelial ovarian cancer
Summary:
BACKGROUND: Survivin is a member of the inhibitors of apoptosis protein family, commonly detected in human cancers and fetal tissue, with the ability to regulate programmed cell death and cell division. Aim of this study is to investigate the immuno-expression of survivin and its correlation with other anti-apoptotic markers (mutant p53 and bcl-2) in human ovarian cancer and assess the prognostic significance and possible therapeutic role of this protein in the future.

MATERIALS AND METHODS: Ninety-two cases of primary epithelial ovarian cancer over a 10-year period were included in the study. Sixty-six cases were diagnosed with serous ovarian cancer and twenty-six with endometrioid. All cases were fixed in formalin and paraffin-embedded standard techniques and processed by Ventana Immunostain method, in order to assess the survivin-positive cases and their prevalence in nucleus or cytoplasm.

RESULTS: Survivin cytoplasmic immuno-expression is associated with more advanced stage and grade of the ovarian disease. Nuclear survivin was more pronounced in tumors with better prognosis. Mutant p-53 and bcl-2 were also positively co-expressed and associated with poor survival rate in all cases of serous ovarian carcinoma. Neither survivin nor bcl-2 was expressed in any case of endometrioid ovarian cancer.

CONCLUSION: Survivin can play a key role as a potential future tumor marker to determine prognosis and predict response to various therapies.
Main subject category:
Health Sciences
Keywords:
Survivin; P53; Bcl-2; Prognosis; Ovary; Cancer
Index:
No
Number of index pages:
0
Contains images:
Yes
Number of references:
217
Number of pages:
123

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