Unit:
Κατεύθυνση Ιατρική Γενετική: Κλινική και Εργαστηριακή ΚατεύθυνσηLibrary of the School of Health Sciences
Author:
Tzouvara Vasiliki
Supervisors info:
Τζέτη Μαρία, Αναπληρώτρια Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ, Επιβλέπουσα
Traeger- Συνοδινού Ιωάννα-Ραχήλ, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Φρυσίρα Ελένη, Ομότιμη Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Δείκτες πρώιμης ανίχνευσης εγκύου υψηλού κινδύνου για την εμφάνιση προεκλαμψίας
Translated title:
Biomarkers for the early identification of women at risk for preeclampsia
Summary:
Background: Preeclampsia (PE) is a complication of pregnancy that affects 2-5% of women during pregnancy, causing serious health effects for both the woman and the fetus. If PE is not diagnosed in its early stages and treated promptly, it can lead to death. Therefore, it is necessary to discover new markers and to study further the already existing ones, in order to detect the disorder in its early stages.
Aim: The aim of this thesis is to review the international literature on early detection markers in high risk pregnancies to develop PE and their potential use as diagnostic and predictive tool. The results of research which identify new markers for PE prediction emphasizing on miRNAs are also analyzed.
Conclusions: The best combined tests include maternal risk factors, MAP, PlGF and UtPI. If it is not possible to measure PlGF and/or UtPI, the tests should be a combination of maternal risk factors with MAP and, not only maternal risk factors and her medical history. If PAPP-A is measured as part of 1st trimester prenatal screening for fetal aneuploidy, the test results may be included for PE risk assessment. A pregnant woman is considered in high risk if the risk is 1% or more, based on the 1st trimester combined with maternal risk factors, MPA, UtPI and PlGF in mother’s serum. PE is a life-threatening disorder that needs to be dealt early on, before its symptoms become noticeable. This will only be possible by further studying the biomarkers that can help identify the disorder early.
Main subject category:
Health Sciences
Keywords:
Preeclampsia, Biomarkers, Biochemical markers, Proteins, microRNAs
Number of references:
114
