Title:
Proteostasis network deregulation as a main molecular link of ageing and carcinogenesis
Languages of Item:
English
Abstract:
Organisms are constantly challenged by stressors and thus the maintenance of biomolecules functionality is essential for the assurance of cellular homeostasis. Proteins carry out the vast majority of cellular functions by mostly participating in multimeric protein assemblies that operate as protein machines. Cells have evolved a complex proteome quality control network for the rescue, when possible, or the degradation of damaged polypeptides. Nevertheless, despite these proteostasis ensuring mechanisms, new protein synthesis, and the replication-mediated dilution of proteome damage in mitotic cells, the gradual accumulation of stressors during ageing (or due to lifestyle) results in increasingly damaged proteome and, consequently, proteome instability. This outcome may then increase genomic instability due to reduced fidelity in processes like DNA replication or repair. Recent findings supporting the notion that proteostasis network deregulation is a main hallmark of ageing and carcinogenesis will be presented. Furthermore, the idea that activation of the proteostasis ensuring mechanisms in premalignant cells has tumor-preventive effects, whereas their inhibition provides a strategy for the development of anti-tumor therapies will be discussed.
Authors:
Ioannis P. Trougakos
Publisher:
HELLENIC SOCIETY FOR BIOLOGICAL SCIENCES
Conference title:
39th ANNUAL CONFERENCE OF THE HELLENIC SOCIETY FOR BIOLOGICAL SCIENCES
Keywords:
Proteostasis, Carcinogenesis, Ageing
Main subject category:
Health Sciences
Project information:
EU grants TASCMAR (EU-H2020), MICROSMETICS (FP7-PEOPLE-IAPP), MEDIHEALTH (EU-H2020)
