Unit:
Faculty of MedicineLibrary of the School of Health Sciences
Dissertation committee:
Νικόλαος Ζακόπουλος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ, Επιβλέπων
Μελέτιος Αθανάσιος Δημόπουλος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Πέτρος Σφηκάκης, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Κλειώ Μαυραγάνη, Αναπληρώτρια Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Κίμων Σταματελόπουλος, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Μαρία Ελευθερία Ευαγγελοπούλου, Επίκουρη Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Ευστάθιος Μανιός, Επίκουρος Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Μελέτη ανοσολογικών παραμέτρων χυμικής και κυτταρικής ανοσίας σε άτομα με ιδιοπαθή υπέρταση και συσχέτιση αυτών με φυσιολογικές μεταβλητές του κυκλοφορικού συστήματος
Translated title:
Study of immune parameters of chemical and cellular immunity in individuals with idiopathic hypertension and their correlation with normal variables of the circulatory system
Summary:
Hypertension is a multifactorial disorder with serious complications and unknown etiology. Among potential contributors, immune dysregulation has been also proposed. The study population included 61 consecutive hypertensive patients and 55 healthy individuals of similar age and sex distribution. All study participants underwent a thorough evaluation for subclinical atherosclerosis. A full immunological profile including quantification of immunoglobulins (IgG, IgM, IgA) and lymphocyte subpopulations was also obtained. Immunoglobulin levels IgG, IgA and IgM and complement factor C3 were found to be significantly increased in the hypertensive compared to the HC group while a statistically significant decrease in peripheral blood CD3+,CD4+ and CD8+ in hypertensive patients versus controls was detected. These findings might support a putative involvement of altered cellular and humoral immune responses in the parthenogenesis of hypertension, implying a promising role for immunomodulatory strategies, already implemented in the treatment of autoimmune diseases, in the future management of hypertension.
Main subject category:
Health Sciences
Keywords:
Hypertension, Cardiovascular disease, Humoral / Cellular immune responses, T-cells, B-cells, Immunoglobulins
Number of references:
107
File:
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Sereti Eleni PhD.pdf
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