Unit:
Κατεύθυνση Διεθνής Ιατρική - Διαχείριση Κρίσεων ΥγείαςLibrary of the School of Health Sciences
Author:
Saridakis Zacharias
Supervisors info:
Πικουλής Εμμανουήλ, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ, Επιβλέπων
Γεωργόπουλος Σωτήριος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Καραβοκυρός Ιωάννης, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Endomyocardial fibrosis and Chagas disease: The neglected cardiomyopathies and the promising role of cardiac magnetic resonance in diagnosis. A systematic review
Translated title:
Endomyocardial Fibrosis and Chagas Disease: the neglected cardiomyopathies and the promising role of CMR in diagnosis.A Systematic Review
Summary:
Endomyocardial fibrosis(EMF) and Chagas Disease(ChD) constitute the so-called neglected cardiomyopathies.EMF, a disease of unknown etiology, endemic in Equatorial Africa is the most common restrictive cardiomyopathy in the world. Mysteriously large fibrotic plagues occupy the cardiac apex and the subvalvular apparatus. Chagas disease, highly endemic in Latin America, is a zooanthroponosis caused by the protozoa Trypanosoma Cruzi. Notwithstanding that the epidemiology of the two diseases is very distinct it seems they also share similarities. Endemicity to the tropics, strong correlation with poverty and parasitic infections, poorly understood and insidious natural course, lack of effective treatment, poor prognosis, appearance in non-endemic settings and high misdiagnosis rates characterize these conditions and justify their characterization as “neglected”. Cardiac magnetic resonance (CMR), a novel imaging modality with capability of tissue characterization could illuminate the course of the diseases and play a crucial role in early diagnosis and risk stratification. In an attempt to raise awareness of the forgotten cardiomyopathies, We conducted a systematic review of the literature including the application of CMR as a novel
diagnostic weapon.
Main subject category:
Health Sciences
Keywords:
Endomyocardial fibrosis, Endomyocardial sclerosis, Chagas disease, Chagasic cardiomyopathy, Restrictive cardiomyopathy, CMR, MRI, Late gadolinium enhancement
Number of references:
138
