Faculty of Medicine
Library of the School of Health Sciences

2020-07-27

2020

Giannios Christos

Ευαγγελία Χαρμανδάρη, Καθηγήτρια , Ιατρική Σχολή, ΕΚΠΑ, Επιβλέπουσα
Γεώργιος Χρούσος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Γεράσιμος Κολαΐτης, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Κυριακή Καραβανάκη, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Φλώρα Μπακοπούλου, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Στυλιανός Χριστόγιωργος, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Αικατερίνη Παπανικολάου, Αναπληρώτρια Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ

Η επίδραση της βιταμίνης D στην αντιμετώπιση των μεταβολικών διαταραχών σε παιδιά και εφήβους με παχυσαρκία

Greek

The effect of vitamin D supplementation on cardiometabolic risk factors and mental health symptoms in obese children

Objective: Decreased 25(OH)-vitamin D concentrations represent a risk factor for the development of cardiometabolic and mental health disorders in adults. We investigated the effect of vitamin D supplementation on cardiometabolic risk factors and mental health symptoms in overweight and obese children and adolescents with vitamin D deficiency or insufficiency.
Patients and Methods: Two hundred and twenty (n=220) overweight and obese children and adolescents [Mean age ± SEM: 10.24±0.17 years; BMI ± SEM: 26.69±0.28 kg/m2; BMI z-score ± SEM: 2.42±0.07; males: 114 (51.8%), females: 106 (48.2%)] with vitamin D deficiency or insufficiency were studied prospectively and randomly assigned into the supplementation (n=109) or the control group (n=111). Participants in the supplementation group received 50,000 IU cholecalciferol once weekly for 6 weeks followed by a maintenance dose. Blood samples for determination of 25(OH)-vitamin D, endocrinologic and cardiometabolic parameters were obtained at baseline and 12 months later. Systolic and diastolic blood pressure was determined twice and the mean value was calculated. Mental health was assessed by questionnaires at baseline and 12 months later.
Results: Subjects in the supplementation group had significantly lower BMI (p=0.010), hsCRP (p=0.048) and total cholesterol (p=0.015), and higher HDL (p<0.001) concentrations than the control group. In addition, they demonstrated significantly lower scores in anxiety, attention problems, aggressive behavior, externalizing problems, attention deficit hyperactivity problems and oppositional defiant problems than the control group.
Conclusions: Vitamin D supplementation may prevent the development of cardiometabolic risk manifestations and may improve anxiety-related, externalizing (behavioral) and internalizing (emotional) problems in overweight and obese children and adolescents with vitamin D deficiency or insufficiency.

Health Sciences

Children and adolescents, Vitamin D, Treatment, Obesity, Metabolic syndrome, Mental health

Yes

2

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https://pergamos.lib.uoa.gr/uoa/dl/object/2920489