Long term follow-up of children born post documented primary, and possibly acute toxoplasma infection during pregnancy

Postgraduate Thesis uoadl:2928429 1 Read counter

Κατεύθυνση Παιδιατρική Λοιμωξιολογία
Library of the School of Health Sciences
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Triantafyllou Anastasia-Rafaela
Supervisors info:
Βασιλική (Βάνα) Παπαευαγγέλου, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Αναστασία Αντωνιάδου, Αναπληρώτρια Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Αλεξάνδρα Σολδάτου, Αναπληρώτρια Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Καταγραφή της μακροχρόνιας παρακολούθησης παιδιών που γεννήθηκαν μετά από επιβεβαιωμένη οξεία και πιθανώς οξεία τοξοπλάσμωση στην κύηση
Translated title:
Long term follow-up of children born post documented primary, and possibly acute toxoplasma infection during pregnancy
Most cases of congenital toxoplasmosis are asymptomatic at birth. High-risk neonates should be tested thoroughly, while treatment administration decreases the incidence of complications. The aim of this retrospective cohort study was to collect medical data on the long-term follow-up of children born after documented primary, and possibly acute toxoplasma infection during gestation. Data was collected from two outpatient clinics on gestational infections (Attica, 2006-2019). Women were interviewed by phone and asked about their offspring-most recent toxoplasma immunoglobulin G (IgG) test results and results from the latest ocular examination. Overall, 75/95 women responded and 76 children were enrolled. All mothers received treatment and 59 underwent amniocentesis. Although 7 amniocenteses were positive by PCR none was confirmed by culture. All 76 children were tested as neonates for toxoplasmosis, 9 received treatment for a median of 5 months, two babies were treated for 12 months. Most children (74/76) were tested negative for toxo-IgG antibodies and all had normal fundoscopy. The PPV of PCR on amniotic fluid was 28,6%. Among the 37 women with possibly acute toxoplasmosis, none had positive PCR results on amniotic fluid and no child out of 39 in total was diagnosed with CT. Since most children lost transplacentally transferred maternal antibodies, one may postulate that toxoplasma DNA detection by PCR in amniotic fluid was false positive. The need for referral to specialized clinics to ensure treatment and follow up is evident.
Main subject category:
Health Sciences
Congenital toxoplasmosis, Follow-up, Fundoscopy, IgGs antibodies
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