The rationale of prophylactic inhaled corticosteroids (ICS)prescription in children with bronchiectasis

Postgraduate Thesis uoadl:2928750 21 Read counter

Unit:
Κατεύθυνση Παιδιατρική Πνευμονολογία
Library of the School of Health Sciences
Deposit date:
2020-11-19
Year:
2020
Author:
Sardeli Olympia
Supervisors info:
Δούρος Κων/νος, Αναπλ.Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Πρίφτης Κων/νος, Αναπλ.Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Αλεξοπούλου Ευθυμία, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Η χρήση εισπνεόμενων κορτικοστεροειδών σε παιδιά με βρογχεκτασίες
Languages:
Greek
Translated title:
The rationale of prophylactic inhaled corticosteroids (ICS)prescription in children with bronchiectasis
Summary:
Background: Bronchiectasis and asthma may share some characteristics and some patients may have both conditions.
Aim: The present study aimed to examine the rationale of prophylactic inhaled steroids prescription in children with bronchiectasis
Methods: Data of children attended in the pediatric pulmonology department of “Attikon” hospital with radiologically established non-CF bronchiectasis were retrospectively reviewed. Episodes of dyspnea and wheezing, spirometric indices, total serum IgE, blood eosinophil counts, sensitization to aeroallergens, and air-trapping on expiratory CT scans, were recorded.
Results: The study included 65 children 1.5 – 16 years old, with non-CF bronchiectasis. Episodes of dyspnea or wheezing were reported by 22 (33.8%) and 23 (35.4%), respectively. Skin prick tests to aeroallergens (SPT) were positive in 15 (23.0%) patients. Mosaic pattern on HRCT was observed in 37 (56.9%) patients. Dyspnea, presence of mosaic pattern, and positive SPT were significantly correlated with the prescription of ICS.
Conclusion: The prescription of ICS in children with bronchiectasis is more likely when there are certain asthma-like characteristics. The difficulty to set the diagnosis of real asthma in cases of bronchiectasis may justify the decision of clinicians to start an empirical trial with ICS in some cases.
Main subject category:
Health Sciences
Keywords:
Bronchiectasis, Inhaled corticosteroids, Children
Index:
No
Number of index pages:
0
Contains images:
No
Number of references:
107
Number of pages:
80

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