The GELA histological grading system and its application in daily practice as a reliable and effective way to monitor patients with gastric MALT lymphoma after treatment

Postgraduate Thesis uoadl:2929107 25 Read counter

Unit:
Κατεύθυνση Εργαστηριακή / Βασική Έρευνα
Library of the School of Health Sciences
Deposit date:
2020-11-24
Year:
2020
Author:
Provatas Ioannis
Supervisors info:
Κουτσιλιέρης Μιχαήλ, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Βαϊόπουλος Γεώργιος, Ομότιμος Καθηγητής, Ιατρική Σχολή, ΕKΠΑ
Ροντογιάννη Δήμητρα, Συντονίστρια Διευθύντρια, Τμήμα Παθολογικής Ανατομικής, Γ.Ν.Α. Ο Ευαγγελισμός- Οφθαλμιατρείο Αθηνών-Πολυκλινική
Original Title:
Το σύστημα ιστολογικής βαθμοποίησης GELA και η εφαρμογή του στην καθημερινή πρακτική ως αξιόπιστος και αποτελεσματικός τρόπος παρακολούθησης ασθενών με λεμφώματα MALT στομάχου μετά από θεραπεία
Languages:
Greek
Translated title:
The GELA histological grading system and its application in daily practice as a reliable and effective way to monitor patients with gastric MALT lymphoma after treatment
Summary:
Marginal zone lymphomas are a distinct type of non-Hodgkin B-lymphomas and they are classified into three categories: Splenic, Nodal, and Extranodal, the latter most commonly associated with mucosal lymphoid tissue. These are lymphomas consisting of small B neoplastic lymphocytes with morphological features of marginal zone lymphocytes, monocytes, small and scattered immunoblasts as well as lymphocytes simulating centroblasts, sometimes with plasmacytic differentiation. The extranodal marginal zone lymphomas develop in sites where normally there is no organized lymphatic tissue, but it is formed as a consequence of antigenic irritation - infection, activation of autoimmune mechanisms or as a result of molecular and genetic phenomena. Gastric mucosa-associated lymphoid tissue (MALT) lymphomas are the most common type of gastric primary lymphomas and they are strongly associated with Helicobacter pylori infection. The determinants for their diagnosis and treatment are gastroscopy and histological examination. Treatment most often involves the eradication of Helicobacter pylori and after its completion gastroscopies are performed on a regular basis with multiple biopsies. The evaluation of histological findings at this stage has a very important role, a fact that makes imperative the need for an easy and practical system for grading and classification of these findings, always with the aim of adopting the optimal monitoring and further treatment strategy for patients that have received treatment. One such system is the GELA treatment response grading system for gastric MALT lymphomas, which classifies histological findings into four categories (CR, pMRD, rRD, NC), facilitating immediate decision making during patient follow-up, being an easy to use and practical tool for clinicians and especially for attending physicians.
Main subject category:
Health Sciences
Keywords:
Lymphoma, B-lymphocytes, MALT, Treatment, GELA, Staging
Index:
No
Number of index pages:
0
Contains images:
Yes
Number of references:
55
Number of pages:
50
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