Unit:
Κατεύθυνση Αποκατάσταση Βλαβών Νωτιαίου Μυελού. Διαχείριση του πόνου Σπονδυλικής προέλευσηςLibrary of the School of Health Sciences
Supervisors info:
Μαρία Ελευθερία Ευαγγελοπούλου, Επίκουρη Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Ιωάννης Βλάμης, Επίκουρος Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Δημήτριος Στέργιος Ευαγγελόπουλος, Ακαδημαϊκός Υπότροφος, ΕΚΠΑ
Original Title:
Η χρήση της βοτουλινικής τοξίνης στην αντιμετώπιση της νευρογενούς κύστης μετά από κάκωση νωτιαίου μυελού
Translated title:
The use of botulinum toxin in the treatment of neurogenic bladder following spinal cord injury
Summary:
Spinal cord injury patients suffer from neurogenic lower urinary tract dysfunction, associated with symptoms of urinary incontinence (UI), urgency and frequency, which may affect upper urinary tract function and has a negative impact on health-related quality of life.
Botulinum toxin is a neurotoxin derived from the bacterium Clostridium botulinum. Dykstra et al, in 1988, first injected 100 BoNT-A units into the external urethral sphincter to treat patients with spinal cord injury.
The aim of this study is to search in the literature about the effectiveness, safety and side effects of botulinum toxinin treatment of neurogenic bladder (NB) due tospinal cord injuries (SCI)
Botulinumtoxin is an effective and safe option for the management of neurogenic bladder in patients who have an inadequate response to, or are intolerant of, oral medication. In SCI patients with neurogenic detrusor overactivity (NDO), botulinum toxin injection significantly decreased UI and detrusor pressure, thus increasing bladder capacity and quality of life.
Main subject category:
Health Sciences
Keywords:
Botulinum toxin, Neurogenic bladder, Overactive detrusor, Spinal cord injury
