Dissertation committee:
Ευάγγελος Γεωργίου, Καθηγητής (συνταξ.), Ιατρική Σχολή, Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών
Παντελής Καραΐσκος, Καθηγητής, Ιατρική Σχολή, Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών
Ιωάννης Σεϊμένης, Καθηγητής, Ιατρική Σχολή, Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών
Θωμάς Μαρής, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, Πανεπιστήμιο Κρήτης
Λουκάς Αστρακάς, Επίκουρος Καθηγητής, Ιατρική Σχολή, Πανεπιστήμιο Ιωαννίνων
Κωνσταντίνος Λουκάς, Επίκουρος Καθηγητής, Ιατρική Σχολή, Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών
Βασίλειος Κουτουλίδης, Επίκουρος Καθηγητής, Ιατρική Σχολή, Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών
Translated title:
Optimization of the signal to noise ratio in localized in vivo magnetic resonance spectroscopy, and of the accuracy of the simultaneous quantitative determination of the hepatic fat infiltration and iron concentration
Summary:
The doctoral thesis comprises two main research topics. The first one involved the optimization of the signal to noise ratio (per unit time), in localized in vivo magnetic resonance spectroscopy, for SVS (single voxel spectroscopy) spectroscopic techniques.The second one was about the simultaneous quantitative specification of the fat infiltration and the iron concentration of the liver. Furthermore, a model was developed, along with the appropriate signal equation, treating the water protons and the fat protons as distinct entities. This was compared statistically with other methods most commonly used for the determination of these parameters (fat infiltration and hepatic iron concentration).
Keywords:
MRI, Quantitative MRI, Optimization, Signal to noise ratio per unit time, Multi-echo gradient-echo