Pharmacokinetic study of colistin after intravenous administration of colistin methanosulfate sodium (CMS) in hemodialysis patients in intensive care unit

Postgraduate Thesis uoadl:2933500 107 Read counter

Unit:
Κατεύθυνση Κλινική Φαρμακευτική
Library of the School of Science
Deposit date:
2021-01-26
Year:
2021
Author:
Karanasiou Nikoleta
Supervisors info:
Γεωργία Βαλσαμή, Καθηγήτρια, Τμήμα Φαρμακευτικής, ΕΚΠΑ
Original Title:
Μελέτη της φαρμακοκινητικής της κολιστίνης μετά από ενδοφλέβια χορήγηση με τη μορφή του μεθανοσουλφονικού εστέρα (CMS) σε αιμοκαθαιρόμενους ασθενείς στη μονάδα εντατικής θεραπείας.
Languages:
Greek
Translated title:
Pharmacokinetic study of colistin after intravenous administration of colistin methanosulfate sodium (CMS) in hemodialysis patients in intensive care unit
Summary:
The aim of this thesis is the determination of basic pharmacokinetic parameters of colistin after intravenous administration of colistin methanesulfonate (CMS). During the pharmacokinetic analysis, the plasma levels of colistin in hemodialysis patients in the intensive care unit were determined, after intravenous administration of CMS, a prodrug which is hydrolyzed in vivo to the active drug colistin. The dosing scheme was a loading dose of 9 MIU and a maintenance dose of 4,5 MIU every 12 hours. The bioanalytical method used to measure colistin in plasma was a high-performance liquid chromatography with fluorescence detection (HPLC-Fluoresce detection). For the pharmacokinetic analysis, concentration - time data, were used. The calculated values of the drug’s concentration at steady state, according to the above dosing scheme, achieved the clinical target according to EMA and FDA guidelines (except two). The study is ongoing with the addition of a larger number of patients.
Main subject category:
Science
Other subject categories:
Health Sciences
Keywords:
antibiotic therapy, resistant microorganisms, instrumental analysis, colistin methyl sulfate, pharmacokinetic analysis.
Index:
Yes
Number of index pages:
0
Contains images:
Yes
Number of references:
165
Number of pages:
100
File:
File access is restricted until 2024-04-02.

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