Impact of probiotics administration on body composition analysis, metabolic factors and gut microbiome in adolescents with prediabetes

Doctoral Dissertation uoadl:2937341 109 Read counter

Unit:
Library of the School of Health Sciences
Faculty of Medicine
Deposit date:
2021-03-02
Year:
2021
Author:
Stefanaki Charikleia
Dissertation committee:
Γεώργιος Χρούσος, Ομότιμος Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Ελευθερία Ρώμα-Γιαννίκου, Ομότιμη Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Εμμανουήλ Δουζίνας, Ομότιμος Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Γεώργιος Μαστοράκος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Αθανάσιος Μίχος, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ, Επιβλέπων
Φλώρα Μπακοπούλου, Αναπληρώτρια Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Αρτεμησία Τσίτσικα, Αναπληρώτρια Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Επίδραση των προβιοτικών στην ανάλυση της σύστασης του σώματος στους μεταβολικούς παράγοντες και στην εντερική χλωρίδα εφήβων με προδιαβήτη
Languages:
Greek
Translated title:
Impact of probiotics administration on body composition analysis, metabolic factors and gut microbiome in adolescents with prediabetes
Summary:
Dysbiosis of intestinal ecology seems to be implicated in prediabetes. The aim of this study was to collect preliminary data on the effects of probiotic supplementation on markers of body composition, glucose metabolism, intestinal microbiome composition, and intestinal health indices, of prediabetic adolescents. The intervention group was administered probiotic sachets twice daily for 4 months, while both intervention and control groups received weekly consultation sessions for a healthier lifestyle. Thirty-two participants were recruited and were randomized (16 in control and 16 in intervention group). Fifteen of them signed the inform consent and never entered the study (6 in control and 9 in intervention group). Thus, seventeen participants completed the study (10 in control and 7 in intervention group), with no serious adverse events. After the 4-month intervention, no difference was observed in the markers of glycemic control between the two groups, although a minor effect was observed for fasting glucose at 1-month, probably due to the initial higher adherence to the probiotic supplements. Modifications of the protocol procedures are warranted because of the high attrition rates and suboptimal compliance that were noted. Future studies and further RCTs with larger samples need to be conducted to fully elucidate the potential effects of probiotics in the glycemic control of prediabetic adolescents.
Main subject category:
Health Sciences
Keywords:
Microbiome, Adolescence, Gut Microbiome, Probiotics, Prediabetes
Index:
No
Number of index pages:
0
Contains images:
Yes
Number of references:
302
Number of pages:
145
File:
File access is restricted only to the intranet of UoA.

Stefanaki Charikleia PhD.pdf
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