Management of the organ donor in the Intensive Care Unit

Postgraduate Thesis uoadl:2937815 31 Read counter

Κατεύθυνση Εντατική και Επείγουσα Νοσηλευτική
Library of the School of Health Sciences
Deposit date:
Katsigianni Konstantina
Supervisors info:
Παύλος Μυριανθεύς, Καθηγητής, Τμήμα Νοσηλευτικής, ΕΚΠΑ
Θεόδωρος Κατσούλας, Αναπληρωτής Καθηγητής, Τμήμα Νοσηλευτικής, ΕΚΠΑ
Άννα Κορομπέλη, ΕΔΙΠ , Τμήμα Νοσηλευτικής, ΕΚΠΑ
Original Title:
Η διαχείριση του δότη οργάνων στη Μονάδα Εντατικής Θεραπείας
Translated title:
Management of the organ donor in the Intensive Care Unit
Introduction-Background: Organ donation saves lives and is the most effective treatment available for end-stage failure of certain organs. Unfortunately, there is a growing gap between the number of donors and the number of patients in waiting lists for a transplant. The persistent deficit in transplantable organs along with the limited scientific evidence guiding the clinical management of the organ donor, justify the need for management strategies resulting from clinical trials in order to improve the care provided to donors and recipient outcomes, while reducing the gap between transplantation needs and organ supply.
Aim: The objective of this thesis was to evaluate the effects of available treatments or interventions of the deceased, solid-organ donor on graft function and / or survival after transplantation.
Methodology: Pubmed and Cochrane library databases were systematically searched for randomized controlled trials that compared deceased-donor treatment versus placebo or no treatment.
Results: Of the 5,894 studies found during the search, 33 were included in this thesis. Clinical benefits in the management of the deceased donor were presented mainly by therapeutic hypothermia, ischemic pre-conditioning and hemodynamic support of the donor with the administration of medical agents (dopamine, prostaglandin I2, low molecular weight colloid hydroxylethyl starch).
Conclusions: There is currently insufficient data to conclude that any particular drug treatment or specialized intervention that can be applied and administered to the deceased donor and are part of the standard donor management that can improve the quality of the graft or the survival of the patient after transplantation.
Main subject category:
Health Sciences
Brain death, Deceased organ donor, Management
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ΜΔΕ_Η διαχείριση του δότη οργάνων στη ΜΕΘ_ΚΩΝΣΤΑΝΤΙΝΑ ΚΑΤΣΙΓΙΑΝΝΗ.pdf
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