Κατεύθυνση Έρευνα στην Γυναικεία Αναπαραγωγή
Library of the School of Health Sciences

2021-04-07

2021

Dionysopoulou Sofia

Γεώργιος Μαστοράκος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Ευαγγελία Χαρμανδάρη, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Γεώργιος Βαλσαμάκης, Διδάκτωρ, Ιατρική Σχολή, ΕΚΠΑ

The role of hypothalamic inflammation in diet-induced obesity and its association with cognitive and mood disorders

Greek

The role of hypothalamic inflammation in diet-induced obesity and its association with cognitive and mood disorders

The prevalence of obesity has been increasing during the last decades. Moreover, epidemiological studies have shown that obesity often coexist with cognitive and mood disorders. It is known that obesity is characterized by low-grade inflammation. Recent evidence suggests that high-fat diet and obesity may cause hypothalamic inflammation. The aim of this review is to summarize the evidence regarding the possible physiopathologic relationship between diet- and/or obesity-induced hypothalamic inflammation with cognitive and mood disorders. Inflammation may influence hypothalamic inter-connections with regions important for cognition and mood while it may cause dysregulation of the Hypothalamus Pituitary Adrenal axis and influence monoaminergic systems. Exercise, healthy diet and glucagon-like peptide receptor agonists, which can reduce hypothalamic inflammation in obese models, could improve the deleterious effects on cognition and mood.

Health Sciences

Diet, Obesity, Hypothalamic inflammation, Cognitive disorders, Mood disorders, Dementia, Depression

No

0

Yes

204

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https://pergamos.lib.uoa.gr/uoa/dl/object/2942595