Isatuximab- Clinical development of isatuximab in patients with multiple myeloma

Postgraduate Thesis uoadl:2944731 9 Read counter

Κατεύθυνση Κλινικές Μελέτες: Σχεδιασμός και Εκτέλεση
Library of the School of Health Sciences
Deposit date:
Dipla Kleopatra
Supervisors info:
Ευάγγελος Τέρπος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Γαβριατοπούλου Μαρία. Επίκουρη Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Καστρίτης Ευστάθιος, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Isatuximab- Η κλινική ανάπτυξη του isatuximab σε ασθενείς με πολλαπλό μυέλωμα
Translated title:
Isatuximab- Clinical development of isatuximab in patients with multiple myeloma
The aim of this study was to analyze the clinical significance of Isatuximab in patients with multiple myeloma. Multiple myeloma is a plasma cell malignancy within the bone marrow that interferes with normal bone marrow function and isatuximab is a monoclonal antibody (mAb) used to treat the disease. Specifically, phase I, phase II and phase III studies are analyzed where isatuximab is studied as monotherapy, but also as a combination of therapies. Each chapter corresponds to a study
analysis and includes subcategories such as isatuximab suitability, study design, study objectives, safety and efficacy evaluations of isatuximab, pharmacokinetic evaluations and statistics, just a few of which will be analyzed. extensively presenting the corresponding tables and diagrams. It is particularly important that the research effort to treat the disease is intensive and as a result of this effort new drugs have been added to treat it in recent years, but newer drugs are also in an advanced stage of development or have been approved for the treatment of certain categories of patients with myeloma. For the correct treatment of the disease and due to its peculiarities in terms of treatment and monitoring, it is recommended to be treated in specialized centers. It is also important, when a clinical protocol is available, for patients with multiple myeloma to join and receive treatment within clinical protocols, in order to have the opportunity to gain access to innovative treatments.
Main subject category:
Health Sciences
Isatuximab, Multiple myeloma
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