Unit:
Faculty of MedicineLibrary of the School of Health Sciences
Author:
Parthenis Christos
Dissertation committee:
Περικλής Παναγόπουλος, Επίκουρος Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Σωτήριος Τσιόδρας, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Χαράλαμπος Χρέλιας, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Σοφία Καλανταρίδου, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Ιωάννης Παναγιωτίδης, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Αναστασία Αντωνιάδου, Αναπληρώτρια Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Νικόλαος Βραχνής, Αναπληρωτής Καθηγητής , Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Μοριακή επιδημιολογία και μικροβιολογία σεξουαλικώς μεταδιδόμενων νοσημάτων
Translated title:
Molecular epidemiology and microbiology of sexually transmitted diseases
Summary:
SUMMARY
Objective: To investigate the diagnosis of sexually transmitted infections (STIs) with human papillomavirus (HPV) infection and the presence of cytological changes in the cervix in a cohort of sexually active women in Greece.
Methods: Cervical cytology testing and the molecular typing of HPV and other STIs were performed for 345 sexually active women aged between 18 and 45 years (mean 33.2±7.2years) visiting a gynaecology clinic for routine cervical screening. The association of HPV and STI detection with cytological findings was investigated.
Results: HPV was detected in 61 women (17.7%) and STIs in 82 (23.8%). Ureaplasmaspp was the most frequently detected pathogen, which was found in 63 (18.2%) women, followed by Mycoplasma spp (21 women, 25.6%) and Chlamydia trachomatis (five women, 6.1%). HPV positivity only (with no co-presence of STI) was associated with an abnormal cytology (odds ratio 6.9, p<0.001), while women who were negative for both HPV and STIs had a higher probability of a normal cytology (odds ratio 0.36, p<0.01). Sixteen out of the 63 (25.4%) women who tested positive for Ureaplasmaspp, harboured a high-risk HPV type (odds ratio 2.3, p=0.02).
Conclusions: In a population with a high prevalence of Ureaplasmaspp, there was an association of this pathogen with high-risk HPV infection, a finding that needs further elucidation.
Main subject category:
Health Sciences
Keywords:
Molecular epidemiology, Chlamydia, Ureaplasma, Mycoplasma, HPV, Sexually transmitted diseases, Cytology
Number of references:
158
