Personalized, organ-specific dosimetric comparison in patients undergoing diagnostic and treatment planning CT using Monte Carlo simulations

Postgraduate Thesis uoadl:2947841 129 Read counter

Unit:
Κατεύθυνση Ιατρική Φυσική-Ακτινοφυσική
Library of the School of Health Sciences
Deposit date:
2021-06-23
Year:
2021
Author:
Sotiropoulou Varvara
Supervisors info:
Ιωάννης Δαμηλάκης, Καθηγητής, Ιατρική Σχολή, Πανεπιστήμιο Κρήτης
Κώστας Περισυνάκης, Καθηγητής, Ιατρική Σχολή, Πανεπιστήμιο Κρήτης
Θωμάς Μαρής, Καθηγητής, Ιατρική Σχολή, Πανεπιστήμιο Κρήτης
Original Title:
Εξατομικευμένη δοσιμετρική σύγκριση οργάνων από ασθενείς που έχουν υποβληθεί σε εξετάσεις Υπολογιστικής Τομογραφίας για διάγνωση και θεραπεία μέσω εξομοιώσεων Monte Carlo
Languages:
Greek
Translated title:
Personalized, organ-specific dosimetric comparison in patients undergoing diagnostic and treatment planning CT using Monte Carlo simulations
Summary:
In the end of 1960s, the field of radiology accomplished many achievements that spurred the development and application of new medical innovations. One of these is the development of Computed Tomography, whose clinical use was immediately acknowledged and as a result it drew attention, which led to its rapid development. In addition, Computed Tomography except that it consists of last generation systems, is a necessary diagnostic procedure in other medical techniques such as radiotherapy.

However, the conditions of the treatment planning CT (RT-CT) differ from those of simple diagnosis (DCT), as the bed is properly shaped so that it is straight and not concave, which could change the anatomical features in relation to the patient’s placement on the Linac’s bed. As well as, there is also patient’s imobilization with special masks for the head and other equipment for the legs.

However, the disadvantage of patients’ exposure to ionizing radiation is still present, as well as the risk of emergence of stochastic problems, such as the possibility of carcinogenesis. More specifically, the NCRP Report 160 (2009) shows that CT holds 49% of the total medical exposures received by the entire US population.

For the above reasons and motivated by the radiation protection of patients, the purpose of this study was patient specific organ dose comparison between diagnostic CT (DCT) and treatment planning CT (RT-CT), in order to find if there are significant differences.

The ImpactMC program was used for this study, which through Monte Carlo simulations is able to provide accurate and fast dose calculations. In the first part of the present study, dose calculations were performed on CTDI and Anthropomorphic phantoms, in order to validate the parameters entered in the ImpactMC simulations and then the organ doses were calculated in three patients who underwent CT examinations for diagnosis and RT-CT at the General University Hospital of Heraklion during the year 2020.
Main subject category:
Health Sciences
Keywords:
Computed tomography, Diagnosis, Radiotherapy, Treatment planning CT, Organ dose comparisons, Personalized dosimetry, ImpactMC, Monte Carlo simulations
Index:
No
Number of index pages:
0
Contains images:
Yes
Number of references:
17
Number of pages:
81
File:
File access is restricted only to the intranet of UoA.

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