Unit:
Speciality Infectious DiseasesLibrary of the School of Health Sciences
Author:
Vrentzos Emmanouil
Supervisors info:
Αναστασία Αντωνιάδου, Καθηγήτρια, Ιατρικής σχολή, Ε.Κ.Π.Α.
Αντώνιος Παπαδόπουλος, Αναπληρωτής Καθηγητής, Ιατρικής Σχολή, Ε.Κ.Π.Α.
Μιχαήλ Σαμάρκος, Αναπληρωτής Καθηγητής, Ιατρικής Σχολής, Ε.Κ.Π.Α.
Original Title:
Η πρωτεΐνη που δεσμεύει την ηπαρίνη στην παθογένεια της Covid-19
Translated title:
Heparin binding protein in pathogenesis of Covid-19
Summary:
Heparin-binding protein (HBP) is an important and major mediator of inflammation and has been shown to be an important diagnostic and prognostic biomarker of sepsis.
"Sepsis" is a life-threatening malfunction of an organ caused by an unregulated host response to an infection. It is a serious condition with significant morbidity and mortality worldwide, as well as one of the main causes of admission to an Intensive Care Unit. Depending on the stage it is in, it shows great heterogeneity in terms of its manifestation, which makes it difficult to identify, but also imposes the need for a tool that can measure in a timely and reliable manner the immune status of a patient.
From a pathophysiological point of view, HBP has a direct interaction with pathogens, but also with the host cells, acting as an inducer of leukocyte chemotaxis by enhancing the action of cytokines in various tissues. In addition, it appears to affect the vascular endothelium in various ways, leading to an increase in vascular permeability, and its action is crucial in the development of sepsis-induced organic insufficiency.
As of 2019, a new coronavirus strain, SARS-CoV-2, has been identified as the cause of the current COVID-19 pandemic. Severe COVID-19 disease appears to be induced by inflammatory processes involved in activating the host immune response and therefore falls within the definition of sepsis (Sepsis-3). If severe COVID-19 disease is seen as a septic condition, the heparin-binding protein can be evaluated as its diagnostic and prognostic biomarker. Concentrations of HBP and IL-6 at patient admission have been shown to be independent risk factors for mortality within 28 days as well as for the development of severe respiratory failure
Main subject category:
Health Sciences
Keywords:
Heparin binding protein, HBP, Covid19
