Stress Management Intervention for Patients with Multiple Sclerosis

Postgraduate Thesis uoadl:2960487 24 Read counter

Κατεύθυνση Η Επιστήμη του Στρές και η Προαγωγή της Υγείας
Library of the School of Health Sciences
Deposit date:
Panagopoulou Zacharo
Supervisors info:
Αναγνωστούλη Μαρία, Επίκουρη Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Δαρβίρη Χριστίνα, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Χρούσος Γεώργιος, Ομότιμος Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Original Title:
Κλινική Παρέμβαση Διαχείρισης Στρες σε Ασθενείς με Πολλαπλή Σκλήρυνση
Translated title:
Stress Management Intervention for Patients with Multiple Sclerosis
Aim: Multiple sclerosis (MS) is an autoimmune disorder of the central nervous system affecting patients’ well-being and quality of life. Pythagorean Self-Awareness Intervention (PSAI) is a novel non-pharmaceutical intervention with significant benefits both in MS and other chronic diseases. In this study, the longstanding effectiveness of PSAI was investigated.
Method: This was a two-arm quasi-experimental pragmatic trial in relapsing–remitting MS patients (23 in the PSAI and 21 in the control group). PSAI patients received an 8-week training period and then they performed PSAI at home in combination with booster sessions for another 16 weeks. Assessments took place at baseline, 8 weeks, and 24 weeks. These included cognition, fatigue, perceived stress, sleep quality, sense of coherence, lifestyle, loneliness, depression and hair cortisol.
Results: Significant group × time interactions favoring PSAI were found during the first 8-week period for information processing speed, fatigue, perceived stress and lifestyle. However, only verbal memory, information processing speed and lifestyle were found to be significantly improved in the PSAI group during the 24-week follow-up period. There were no significant group × time differences with respect to hair cortisol. No side effects were noted and compliance was excellent.
Conclusions: PSAI was mostly effective for information processing speed, fatigue, perceived stress and lifestyle during the first 8-week training period. However, PSAI effectiveness was maintained only for lifestyle, information processing speed, and verbal memory during the non-training period. Our findings will help to further refine the technique, either by extending the training period and/or booster sessions, throughout the PSAI treatment.
Main subject category:
Health Sciences
Stress; Multiple sclerosis; Intervention; Fatigue; Cognitive function; Quasi-experimental
Number of index pages:
Contains images:
Number of references:
Number of pages:

Διπλωματική Εργασία_ΠΣ-ΣΤΡΕΣ_Παναγοπούλου Ζαχαρώ 2021 ΑΜ20170348.pdf
1 MB
File access is restricted only to the intranet of UoA.