Non-conding RNAs in bone metabolism

Postgraduate Thesis uoadl:2966130 2 Read counter

Κατεύθυνση Μεταβολικά Νοσήματα των Οστών
Library of the School of Health Sciences
Deposit date:
Atudorei Cristina-Elena
Supervisors info:
Σταυρούλα Ρίζου, διδάκτορ Ιατρικής Σχολής , ΕΚΠΑ
Γεώργιος Λάμπρου ,βιολόγος, μέλος ΕΔΙΠ
Γεώργιος Λυρίτης, ομότιμος καθηγητής, ΕΚΠΑ
Original Title:
Μη κωδικά RNAs στον οστικό μεταβολισμό
Translated title:
Non-conding RNAs in bone metabolism
The integrity and proper function of the human skeleton depends on the continuous renewal of bone tissue throughout life, a process that in order to be successful there must be balance between bone formation and bone resorption.
Μillions of people affected by bone diseases worldwide and in recent years their incidence has increased due to the aging population. Over the past decade, however, a large number of medical data have focused on epigenetic factors because there is certainty that they are involved in both bone biology and disease. Epigenetic mechanisms are related to pathways that affect gene expression in the postnatal life without altering the DNA sequence. These mechanisms include DNA methylation, translational histone modifications, and non-coding RNA post-transcription (ncRNA) modulation, with the latter being able to detect inherited phenotypic modifications.
A progressive understanding of the roles that epigenetic mechanisms play in both normal bone metabolism and in causing homeostasis disorders is vital. A complete understanding of bone biology, in addition to being useful for maintaining their normal function, also contributes to the promotion of their good health but also to the understanding of the mechanisms that cause bone diseases.
Recently, lncRNAs, a subset of ncRNAs, have been described as the key regulators of many cellular processes involved in maintaining bone homeostasis and the onset of disease or malignancy. The manner and size of their expression has been shown to be associated with pathological conditions and the manifestation of diseases. The possible control of the regulation of their expression makes them as possible diagnostic, prognostic and therapeutic biomarkers for a wide range of diseases, including cancer.
This review analyzes the role of non-coding RNAs, also known as "DNA dark matter", in bone remodeling, bone cell function, their contribution to the prognosis, detection as well as the treatment of bone diseases.
Main subject category:
Health Sciences
Mesenchymal stem cells, Non-Coding RNAs, Epigenetic, Negative/ Positive Regulators, Biomarkers
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