Κατεύθυνση Κλινική και Πειραματική Νευροχειρουργική
Library of the School of Health Sciences

2022-05-17

2022

Athanasaki Athanasia

Παρασκευάς Γεώργιος, Αναπληρωτής Καθηγητής, Ιατρική σχολή, ΕΚΠΑ
Κούτσης Γεώργιος, Επίκουρος Καθηγητής, Ιατρική σχολή, ΕΚΠΑ
Καλαματιανός Θεοδόσης, Ακαδημαϊκός Υπότροφος ΠΜΣ

Ο ρόλος του σακχαρώδη διαβήτη ως παράγοντα κινδύνου για τη νόσο Αlzheimer

Greek

The role of diabetes mellitus as a risk factor for Alzheimer's disease

Alzheimer’s disease is the most common type of dementia, reaching the 60-80% of the cases’ total, and one of the major causes of elderly population’s decline in functionality, concerning daily life activities, globally. Epidemiological surveys have already revealed that diabetes mellitus type II is a risk factor of Alzheimer disease, such as several others metabolic factors, like dyslipidemia and obesity. In fact, many molecular pathways have been described and at the same time there are clues that suggest the connection between these diseases through specific genes, the autophagy and even the gut microbiota. The main goal of this multilevel connection is the discovery of new therapeutic agents in the future. This study was based on the PRISMA statement and the electronic database of PubMed was searched from January 2008 to May 2021. 18 studies were included in the meta-analysis and 79 studies, in total, were necessary in reviewing the common molecular pathways of these diseases. The present findings suggest that an abnormal glucose metabolism in general, may be associated with an increased risk for developing Alzheimer’s disease in the general population.

Health Sciences

Diabetes mellitus, Alzheimer's disease, Common molecular mechanisms

No

0

Yes

171

64

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https://pergamos.lib.uoa.gr/uoa/dl/object/3217454