Comparative study of radiotherapy techniques for large left breast cancer patients

Postgraduate Thesis uoadl:3217635 28 Read counter

Unit:
Κατεύθυνση Ιατρική Φυσική-Ακτινοφυσική
Library of the School of Health Sciences
Deposit date:
2022-05-17
Year:
2022
Author:
Karageorgiou Maria
Supervisors info:
Παπαναστασίου Εμμανουήλ, Επίκουρος Καθηγητής, Ιατρική Σχολή, ΑΠΘ
Σιούντας Αναστάσιος, Ομότιμος Καθηγητής, Ιατρική Σχολή, ΑΠΘ
Πλατανιώτης Γεώργιος, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΑΠΘ
Original Title:
Συγκριτική μελέτη διαφόρων τεχνικών ακτινοθεραπείας για την ακτινοβόληση ευμεγεθών αριστερών μαστών
Languages:
Greek
Translated title:
Comparative study of radiotherapy techniques for large left breast cancer patients
Summary:
The purpose of this MSc Thesis is to compare dosimetric differences based on four types of radiotherapy plans for large left breast cancer. 3D conformal radiotherapy (3D-CRT) with wedge filters, 3D conformal radiotherapy with Field-in-Field (FIF), Intensity Modulated Radiation Therapy (IMRT) and Volumetric Modulated Arc Therapy (VMAT) plans were generated to evaluate the potential dosimetric benefits and drawbacks of each technique and the possible side effects in relation to the breast size.
For the conduction of this research, four radiotherapy treatment plans, including 3D-CRT with wedge filters, 3D-CRT with Field-in-Field (FIF), Intensity Modulated Radiation Therapy (IMRT) and Volumetric Modulated Arc Therapy (VMAT), were created for twenty-five large left breast cancer female patients with prescription doses of 5000 cGy. 3D-CRT plans were created using VARIAN's ECLIPSE 15.1 treatment planning system and IMRT-VMAT plans using Elekta’s MONACO 5.11.03 treatment planning system of the Radiotherapy Department at “AHEPA” University General Hospital of Thessaloniki. In addition, dose distribution was optimized across the four different treatment plans, with a compromise between maximizing the dose coverage of planning target volume (PTV) and minimizing the dose at organs at risk (ipsilateral lung and heart). Afterwards, some characteristic dosimetric and physical parameters were evaluated, using the IBM SPSS Statistics software.
Therefore, conclusions were drawn on target dose coverage, dose in healthy tissues, Homogeneity Index, Conformity Index, modulation degree, and Monitor Units of each treatment plan. The Sliding Window - IMRT plans achieve better dose coverage for cases of large left breasts and lower mean heart dose compared to other plans. 3D - CRT plans achieve an efficient PTV’s coverage rate and the minimum number of Monitor Units.; FIF technique offers higher PTV dose coverage, lower maximum PTV dose, but higher doses to OARS compared to the WEDGE technique. Finally, the VMAT techinque offers an increased difficulty of plan’s success and higher mean doses at OARs compared to the other techniques.
Main subject category:
Health Sciences
Keywords:
Radiotherapy, Breast cancer, 3DCRT, wedge filters, Field-in-Field (FIF), Sliding Window - IMRT, VMAT, Left-sided breast radiotherapy
Index:
No
Number of index pages:
0
Contains images:
Yes
Number of references:
41
Number of pages:
110
File:
File access is restricted only to the intranet of UoA.

Karageorgiou_Maria_MSc.pdf
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File access is restricted only to the intranet of UoA.