Study of changes in body composition in metabolism and biochemical parameters in patients with pancreatic cancer

Doctoral Dissertation uoadl:3221525 3 Read counter

Κατεύθυνση Κλινικοπαθολογοανατομική θεώρηση των νεοπλασιών του ανθρώπου
Library of the School of Health Sciences
Deposit date:
Antoniadou Dimitroula
Dissertation committee:
Παπαβασιλείου Αθανάσιος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Κασσή Ευανθία, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Καραμούζης Μιχαήλ, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Ζαμπέλας Αντώνιος, Καθηγητής, Γεωπονική Σχολή, ΕΚΠΑ
Σακελλάριου Στρατηγούλα, Επίκουρη Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Αγγελούση Άννα, Επίκουρη Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Πούλια Καλλιόπη Άννα, Επίκουρη Καθηγήτρια, Γεωπονική Σχολή, ΕΚΠΑ
Original Title:
Μελέτη των αλλαγών στη σύσταση σώματος στο μεταβολισμό και σε βιοχημικές παραμέτρους σε ασθενείς με καρκίνο παγκρέατος
Translated title:
Study of changes in body composition in metabolism and biochemical parameters in patients with pancreatic cancer
Cachexia is a major characteristic of multiple advanced and metastatic cancers,
such as pancreatic cancer. It is present in almost 70%-80% of patients with
pancreatic cancer. Cancer cachexia is a multifactorial syndrome characterized by
symptoms such as anorexia, involuntary loss of adipose and skeletal muscle
tissue. It is associated with treatment failure, reduced quality of life, and poor
overall survival. The interplay between tumor and host factors, such as cytokines,
holds a central role in cachexia pathophysiology. Choosing the most appropriate
treatment, the clinical effect and the risk of adverse effects should be taken under
consideration. The present prospective study (from January 2017 until December
2020) aimed to evaluate the interrelation between nutritional parameters at the
initial evaluation with the changes in QOL indicators and the Progression-Free
Survival and Overall Survival in 97 patients with pancreatic cancer. Dietary
and nutritional risk assessment and evaluation of Frailty and Functional Status
were performed. Health- related Quality of Life was evaluated with the EORTC
QLQ-C30 questionnaire. Nutritional risk, as evaluated by MNA-SF score was
negatively associated with age (p = 0.003) and positively associated with
dynamometry (p = 0.001). Also, there was a statistically significant difference in
the financial difficulties (p = 0.049). OS and PFS were found to decrease in
patients who reported having increased fatigue (OS p = 0.007 and PFS p =
0.044). Moreover, higher prevalence of constipation resulted in lower OS and
PFS (OS p < 0.001 and PFS p < 0.001) and increased reporting of gastrointestinal
problems during the 3 months was connected with lower survival (OS p =
0.017). Οur patients were found to have lower OS and PFS, stressing out the
necessity to provide early identification and management to symptoms of the
disease that could compromise nutritional status. The provision of nutritional
advice and guidance is of major importance for the patients.
Main subject category:
Health Sciences
Cachexia, metabolism, survival, worsening, body weight, pancreas, diet
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