Κατεύθυνση Ανάπτυξη Νέων Φαρμάκων: Έρευνα, Κυκλοφορία και Πρόσβαση
Library of the School of Health Sciences

2022-09-22

2022

Panousi Panagiota

Κωνσταντίνος Ν. Συρίγος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Ηλίας Κοττέας, Αναπληρωτής καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Ανδριανή Χαρπίδου, Ακαδημαϊκή υπότροφος, Ιατρική Σχολή, EKΠΑ

Η κλινική και ερευνητική αξία της φαρμακογονιδιωματικής μελέτης

Greek

Clinical and research value of pharmacogenomics

Since ancient times, it has been known that everyone reacts differently to medications,
foods, and generally to the stimuli of their environment. This is largely due to genetic factors.
The term pharmacogenomics refers to the study of genomic variants associated with an
organism's differential response to a particular drug, with the ultimate goal of personalizing
and optimizing treatment. This thesis is a review of the existing literature on
pharmacogenomics, to highlight its clinical and scientific value. The literature search was
conducted mainly through PubMed and the results were carefully evaluated. The results
show that the clinical value of pharmacogenomics study is mainly in helping health
professionals make the right treatment decisions and leading to more targeted, effective,
safe, and cost-effective treatments that significantly improve patients' quality of life and
health and strengthen health care systems. Pharmacogenomics has begun to be integrated
into clinical practice with the help of guidelines issued by organizations such as CPIC and
DPWG, and appears to have great impact and many future prospects in areas such as
oncology, psychiatry, neurology, cardiology, and others, while it can even be very useful in
primary care. At the same time, pharmacogenomics improves pharmaceutical research by
contributing to a better understanding of drug mechanisms of action, disease pathogenesis,
drug-disease interactions, and genetic background of these. In addition to its clinical value,
pharmacogenomics also helps in the research and discovery of new drugs, contributes to
the repurposing of known drugs, and to the optimal design of effective clinical trials through
the rational selection of appropriate participants. Nevertheless, we are only at the beginning and developments in the field of pharmacogenomics are expected to be rapid and impressive in the future.

Health Sciences

pharmacogenetics, pharmacogenomics, clinical , research, drug development, precision medicine

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https://pergamos.lib.uoa.gr/uoa/dl/object/3229385