Unit:
Κατεύθυνση Φαρμακευτική ΧημείαLibrary of the School of Science
Author:
Efstathiou Natasa
Supervisors info:
Ιωάννης Παπαναστασίου, Αναπληρωτής Καθηγητής, Τμήμα Φαρμακευτικής, Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών.
Ανδρέας Τσοτίνης, Καθηγητής, Τμήμα Φαρμακευτικής, Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών.
Αντώνης Κολοκούρης, Καθηγητής, Τμήμα Φαρμακευτικής, Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών.
Original Title:
ΣΥΝΘΕΣΗ ΑΔΑΜΑΝΤΑΝΙΚΩΝ ΓΛΟΥΤΑΜΙΝΕΡΓΙΚΩΝ ΠΑΡΑΓΩΓΩΝ ΚΑΙ ΜΕΛΑΤΟΝΙΝΕΡΓΙΚΩΝ ΠΑΡΑΓΩΓΩΝ ΓΙΑ ΑΝΤΙΚΑΤΑΘΛΙΠΤΙΚΗ ΘΕΡΑΠΕΙΑ
Translated title:
SYNTHESIS OF ADAMANTANE GLUTAMINERGIC DERIVATIVES AND MELATONINERGIC DERIVATIVES FOR ANTIDEPRESSANT THERAPY
Summary:
The present diploma work describes the design and synthesis of new glutamatergic adamantane derivatives and the resynthesis of melatoninergic derivatives for antidepressant treatment. In particular, the 2,2-substituted adamantane cyclic and heterocyclic amines Ia-c as well as the 2-Adamantane carbinols IIa-d were designed and synthesized, where the substitution of the cyclic amines was transferred from the 2-position of adamantane to the 2-position of thiazole. In addition, for the needs of the pharmacological evaluation according to the ketamine/melatonin co-administration protocol, the phenylalkylamides IIIa-c with melatoninergic activity were re-synthesized.
Main subject category:
Science
Keywords:
Antidepressant therapy, Ketamine, Melatonin, Adamantane derivatives, Melatoninergic derivatives
File:
File access is restricted until 2024-05-26.
Διπλωματική NE.pdf
3 MB
File access is restricted until 2024-05-26.
