COVID-19 and invasive candidiasis: one more possible risk factor

Postgraduate Thesis uoadl:3364927 13 Read counter

Κατεύθυνση Αναζωογόνηση
Library of the School of Health Sciences
Deposit date:
Athanasakis Georgios
Supervisors info:
Ξάνθος Θεόδωρος, Καθηγητής, Τμήμα Μαιευτικής, ΠΑΔΑ
Ιακωβίδου Νικολέτα, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Εκμετζόγλου Κωνσταντίνος, Επίκουρος Καθηγητής, Τμήμα Ιατρικής, Ευρωπαϊκό Πανεπιστήμιο Κύπρου
Original Title:
COVID-19 και διηθητική καντιντίαση: ένας ακόμη πιθανός παράγοντας κινδύνου
Translated title:
COVID-19 and invasive candidiasis: one more possible risk factor
The novel coronavirus SARS-CoV2 which appeared at the end of the 2019 in Wuhan, China and
causes the COVID-19 disease which developed into pandemic, lead to a great increase of the
hospital admissions and especially in the Intensive Care Units. Invasive candidiasis is among
the complications of the admission of a long duration and especially in the Intensive Care
Units. There are a lot of studies in literature which record a great number of cases with COVID19 disease and candidemia. The purpose of this study is to investigate whether SARS-COV 2
could be an independent risk factor leading to invasive candidiasis in hospitalized patients.
For this study, a meta-analysis from previous studies in literature took place. These studies
included patients divided into 4 groups. Group 1: Patients with COVID-19 and invasive
candidiasis. Group 2: Patients without COVID-19 with invasive candidiasis. Group 3: Patients
with COVID-19 without invasive candidiasis. Group 4: Patients without COVID-19 nor invasive
candidiasis. The search of the articles took place in the platforms Pubmed, Google Scholar and
Scopus, according to PRISMA Guidelines 2020. There were, finally, 8 articles selected, and the
statistical analysis took place by using the statistical programs Medcalc Analysis, NCSS Analysis,
and Meta-Mar Analysis.
From the statistical analysis using all 3 programs, there was a statistically significant result, by
using for Odds Ratio the Fixed Effect Model and the Random Effect Model. However, due to
the heterogeneity of the sample the preferred model is the Random Effect Model. In all
3programs, the Odds Ratio presented a statistically significant result in favor of the existence
of SARS-CoV 2 as an independent risk factor for invasive candidiasis, whereas using Begg’s Test,
Egger’s Test and Fail-Safe N of Rosenthal, there was not any publication bias.
This study leadsto the conclusion that COVID-19 disease could be an independent risk factor
which leads to candidemia and therefore, to invasive candidiasis. Even though, most of the
patients of the sample were admitted to the Intensive Care Unit, a deal of them was admitted
to the wards and it is observed that there was candidemia as an infection even to them. These
results could lead to an earlier diagnosis and treatment of patients with COVID-19 disease
whose situation deteriorates, and invasive candidiasis could be the reason. To conclude, this
could lead to a great reduction of the mortality and the complications in these patients.
Main subject category:
Health Sciences
SARS-CoV 2, COVID-19, Invasive candidiasis, Candidemia, Intensive Care Unit
Number of index pages:
Contains images:
Number of references:
Number of pages:
Athanasakis_Georgios_MSc.pdf (1 MB) Open in new window