Unit:
Κατεύθυνση ΑναζωογόνησηLibrary of the School of Health Sciences
Author:
Massaras Dimitrios
Supervisors info:
Γεώργιος Γκιόκας, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ, Επιβλέπων
Κασσιανή Θεοδωράκη, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Θεόδωρος Ξάνθος, Καθηγητής, Τμήμα Μαιευτικής, ΠΑΔΑ
Original Title:
Η επίδραση της πυλαιοκοιλικής αναστόμωσης και της χορήγησης ρεγαδενοσόνης στη διηπατική κλίση γαλακτικού και στις συστηματικές αιμοδυναμικές μεταβλητές σε πειραματικό μοντέλο εκτεταμένης ηπατεκτομής. Πειραματική μελέτη σε οικόσιτους χοίρους
Translated title:
The effect of portal-caval anastomosis and regadenoson administration on transhepatic lactate gradient and systemic hemodynamic variables in an experimental model of extensive hepatectomy. Experimental study in domestic pigs
Summary:
Postoperative liver failure is a long-standing and contemporary clinical entity in liver surgery, which has been and continues to be studied in detail due to its complexity and its significant mortality. The main etiologic factor of this complication as revealed by contemporary research is the HABR (hepatic artery buffer response) phenomenon with hepatic artery vasoconstriction as a reaction of portal hyperflow and adenosine leaching from the remaining liver. Ways of dealing with this phenomenon, and thus this serious complication of postoperative liver failure, are both surgical and pharmacological. Surgical techniques are quite limited due to their complexity and their application to selected patients. However, research is promising regarding pharmaceutical agents that can reverse the HABR phenomenon and hepatic artery vasoconstriction. Adenosine is the main substance involved in the pathophysiology of this phenomenon and therefore studies of adenosine analogues are promising. Our research interest and question in the present experimental study is whether the use of regadenoson, an analogue of adenosine and portocaval anastomosis respectively affect hemodynamically the experimental models and whether by measuring lactic acid and transhepatic lactate gradient we observe an improvement in liver function both with the use of portocaval anastomosis and with the use of regadenoson after an extended hepatectomy.
Main subject category:
Health Sciences
Keywords:
Regadenoson, Adenosine, Lactate, Portocaval shunt, Posthepatectomy liver failure
