Dissertation committee:
Ροδολάκης Αλέξανδρος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Δασκαλάκης Γεώργιος, Καθηγητή, Ιατρική Σχολή, ΕΚΠΑ
Δημητρακάκης Κωνσταντίνος, Καθηγητή, Ιατρική Σχολή, ΕΚΠΑ
Παππά Καλλιόπη, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Ντόμαλη Αικατερίνη, Αναπληρώτρια, Ιατρική Σχολή, ΕΚΠΑ
Γρηγοριάδης Θεμιστοκλής, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Σταύρος Σοφοκλής, Επίκουρος Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Summary:
Obesity, a global health issue affecting 650 million individuals of all ages, leads to health complications, including cardiovascular, endocrine, and infertility issues. This research examines the impact of bariatric surgery on women under 40 with obesity, investigating the relationship between the expression of the CART and leptin genes, reproductive hormones, and their correlation with the presence or absence of the Asn680Ser polymorphism of the FSHR gene. Following the intervention, a significant reduction in BMI (16.03 kg/m2, n = 29) was observed, accompanied by significant changes in women's hormonal profiles. FSH levels showed a mean difference of 3.18 ± 1.19 before and after the intervention (p < 0.001), LH levels exhibited a mean difference of 2.62 ± 1.1 (p < 0.001), E2 levels showed a mean difference of 18.62 ± 5.02 (p < 0.001), and AMH levels showed a mean difference of 3.18 ± 1.19 (p < 0.001). High expression of the CART and leptin genes before the intervention was associated with lower expressions afterward. These findings, based on statistically significant correlations (CART: rs = 0.51, p = 0.005; leptin: rs = 0.75, p < 0.001), illuminate potential molecular mechanisms linking gene expression with hormones after bariatric surgery. Additionally, the presence or absence of the Asn680Ser polymorphism of the FSHR gene was investigated. After the intervention, a mean reduction in BMI (16.03 kg/m2) was observed in all women. FSH levels before the intervention varied significantly among different genotypes, with mean values of 8.1, 9.5, and 10.3 for individuals without the polymorphism, homozygotes, and heterozygotes, respectively (p=0.0408). Post-surgery, marginal differences in FSH levels were observed (5.8, 7.1, and 8.2, respectively) (p=0.0356). E2 and LH levels showed no significant differences based on genotype
before and after the intervention. Pre-surgical E2 levels were 29.6, 29.8, and 29.6, respectively (p=0.91634), while post-surgical levels were 51.2, 47.8, and 47 (p=0.7720). LH levels followed similar patterns. The findings highlight the positive impact of bariatric surgery on BMI reduction and its potential connection to genetic markers, hormones, and infertility. This suggests that personalized treatments based on women's genetic profiles offer better outcomes in reproductive capacity for individuals with obesity.
Keywords:
Infertility, Obesity, Gynecology, Bariatrics
