Κατεύθυνση Οργανική Σύνθεση και Εφαρμογές της στη Χημική Βιομηχανία
Library of the School of Science

2024-10-29

2024

Terzi Evangelia

Βασιλείου Σταματία, Καθηγήτρια, Τμήμα Χημείας, ΕΚΠΑ, (Επιβλέπουσα),
Γκιμήσης Αθανάσιος Καθηγητής Τμήμα Χημείας, ΕΚΠΑ,
Γεωργιάδης Δημήτριος Καθηγητής Τμήμα Χημείας, ΕΚΠΑ

Σύνθεση παραγώγων 2-αμινο-θειαζολίου με πιθανό φαρμακολογικό ενδιαφέρον

Greek

Synthesis of 2-amino-thiazole derivatives with pharmacological potential

In this thesis, the synthesis of 2-amino-thiazole derivatives is investigated. In the first chapter, the structural characteristics of 2-amino-thiazoles are analyzed, and a literature review of their synthesis methods is provided, along with an overview of their biological activities, focusing on derivatives that are used as drugs or are potential candidates for pharmaceutical use. In the second chapter the purpose of the study is outlined, while in the third chapter the synthesis processes of various 2-amino-thiazole derivatives is described. Specifically, synthesis methods for 2-amino-thiazole derivatives are presented, such as (N)-thiazolyl cinnamamides, (N)-thiazolyl lipoamides, (N)-thiazolyl sulfonamides, (N)-thiazolyl imines, and 2-formamido-thiazoles. In the fourth chapter the conclusions of the study are summarized, and in the fifth chapter the experimental methods used for the synthesis are described, along with the characterization of the derivatives. The identification and characterization of the compounds was performed using nuclear magnetic resonance spectroscopy (NMR 1H and 13C, NOESY, COSY, HSQC, HMBC) and mass spectrometry (MS).

Science

thiazoles, 2-amino-thiazoles, cinnamamides, sulfonamides, imines, formamides

Yes

1

Yes

87

152

File access is restricted until 2027-10-31.

https://pergamos.lib.uoa.gr/uoa/dl/object/3421702