Unit:
Κατεύθυνση Οργανική Σύνθεση και Εφαρμογές της στη Χημική ΒιομηχανίαLibrary of the School of Science
Author:
Alevizopoulos Nikolaos
Supervisors info:
Γεωργιάδης Δημήτριος, Καθηγητής Τμήμα Χημείας ΕΚΠΑ, 9Επιβλέπων)
Χριστόφορος Κόκοτος, Καθηγητής Τμήμα Χημείας ΕΚΠΑ,
Βικτωρία Μαγκριώτη, Αναπληρώτρια Καθηγήτρια Τμήμα Χημείας ΕΚΠΑ
Original Title:
Διερεύνηση Ρ-Μichael Προσθήκης σε Ακρυλαμίδια Επιταχυνόμενη από Οξύ Lewis για τη Σύνθεση Στερεοχημικά Παρεμποδισμένων Φωσφινικών Ενώσεων
Translated title:
Investigation of P-Michael Addition to Acrylamides Accelerated by Lewis Acid for the Synthesis of Stereochemically Hindered Phosphine Compounds
Summary:
Phosphinic pseudopeptides are an important class of bioactive compounds. Despite
their widespread application in medicinal chemistry and chemical biology, synthetic
methodologies targeting these structures have significant limitations. One consequence
is the inability to apply modern approaches to drug discovery, such as the introduction
of conformational constraints. The objective of this thesis is the development of a new
synthetic protocol that enables the rapid and stereoselective synthesis of non-classical,
poly-substituted phosphinic pseudopeptide structures, with the aim of controlling their
conformational freedom. The method is based on the modification of an existing
approach and involves the P-Michael addition to electrophilic, stereochemically
demanding acrylamides activated by a Lewis acid.
Main subject category:
Science
Keywords:
Organic Synthesis, Phosphinic acid, P-Michael addition, Amide activation
Number of references:
127
File:
File access is restricted until 2027-10-31.
Μεταπτυχιακό 28-10.pdf
4 MB
File access is restricted until 2027-10-31.
