Κατεύθυνση Νοσηλευτική Καρδιαγγειακών Νόσων
Library of the School of Health Sciences

2025-02-18

2025

Gega Maria

Νικόλαος Φώτος, Αναπληρωτής Καθηγητής, Τμήμα Νοσηλευτικής, ΕΚΠΑ
Ηρώ Μπροκαλάκη- Πανανουδάκη, Ομότιμη Καθηγήτρια, Τμήμα Νοσηλευτικής, ΕΚΠΑ
Κωνσταντίνος Γιακουμιδάκης, Αναπληρωτής Καθηγητής, Τμήμα Νοσηλευτικής, ΕΛΜΕΠΑ

Προσήλωση στην ανοσοκατασταλτική αγωγή ασθενών μετά από μεταμόσχευση καρδιάς

Greek

Adherence to immunosuppresive medication of patients after heart transplantation

Introduction: Heart transplantation is the treatment of choice for end-stage heart failure.
After transplantation, lifelong immunosuppressive treatment is required to protect the graft. However, it has been observed that adherence to immunosuppressive treatment is a challenge for patients, which demonstrates the importance of investigating the phenomenon of non-adherence.

Objectives: To investigate adherence to immunosuppressive treatment of patients after
heart transplantation through a systematic review of international literature.

Material and Methods: A systematic review was performed using two databases,
"PubMed" and "Scopus". The included studies were primary, quantitative, published in
English and within the time period 2000-2024. The keywords used for the search were
based on the three main pillars of the research question: “heart transplantation”,
“medication adherence” and “immunosuppressive treatment”..

Results: After searching the literature in the databases, a total of 234 articles were found,
of which 18 were included in the systematic review, based on the inclusion criteria set. The mean age of the participants was between 46-61 years and the majority were male. In addition, the majority of studies used self-report methods to assess adherence to immunosuppressive treatment and only 5 studies used more than one assessment method. Both the degree of adherence and the classification of adherence varied widely in the included studies. Overall adherence was found in 7 studies 24.1% - 46.1% , and in the majority of studies above 50%, with 2 studies reporting a rate above 80%. The dimensions of adherence investigated in the majority of studies were divided into "drug holidays", “taking nonadherence” and “timing nonadherence” to the immunosuppressive treatment , while in the majority the lowest adherence rate was noted in the time of intake.

Conclusions: Adherence to immunosuppressive treatment in patients after heart
transplantation is not sufficient. Further research is needed, using reliable methods to
assess adherence, to investigate the factors leading to non-adherence and to implement
interventions to enhance adherence.

Health Sciences

Heart transplantation, Medication adherence , Immunosuppressive treatment

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https://pergamos.lib.uoa.gr/uoa/dl/object/3465431