Faculty of Medicine
Library of the School of Health Sciences

2025-02-07

2025

Moriki Dafni

Κωνσταντίνος Δούρος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ (Επιβλέπων)
Βασιλική Παπαευαγγέλου, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Αργύριος Ντινόπουλος, Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Κωνσταντίνος Πρίφτης, Αναπληρωτής Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ
Δέσποινα Μπριάνα, Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Σμαραγδή Φεσσάτου, Επίκουρη Καθηγήτρια, Ιατρική Σχολή, ΕΚΠΑ
Λάμπρος Φώτης, Επίκουρος Καθηγητής, Ιατρική Σχολή, ΕΚΠΑ

Μελέτη του εντερικού μικροβιώματος σε παιδιά με υπερευαισθησία στο γάλα αγελάδας

Greek

Study of the gut microbiome in children with hypersensitivity to cow's milk

Introduction: Cow’s milk allergy (CMA) is the most common food allergy in infancy and early childhood. Although gut dysbiosis is associated with CMA, causality remains uncertain. Furthermore, it is not yet clear which specific taxa are involved and by what mechanism.
Aim: This study aimed to identify specific bacterial signatures that influence the development and outcome of the disease. We also investigated the effect of hypoallergenic formula (HF) consumption as a substitute for cow’s milk on the gut microbiome of milk-allergic children.
Methods: The study included 32 children aged 5-12 years with CMA and 36 age-matched healthy controls. Children with CMA were further divided according to whether they had developed oral tolerance (n=18) or not (n=14). Healthy children were divided according to whether they consumed cow's milk (n=26) or not (n=10). 16S rRNA amplicon sequencing was applied to characterize their gut microbiome.
Results: The gut microbiome of children with CMA differed significantly from that of healthy children, regardless of whether they consumed cow’s milk. Compared to that of healthy cow's milk consumers, the gut microbiome of children with CMA was depleted in Bifidobacterium, Coprococcus catus, Monoglobus, and Lachnospiraceae GCA-900066575, while being enriched in Oscillibacter valericigenes, Negativibacillus massiliensis, and three genera of the Ruminococcaceae family. Of these, only the Ruminococcaceae taxa were also enriched in healthy children not consuming cow’s milk, suggesting that differences in other taxa would rather be specifically associated with the disease itself. Furthermore, the gut microbiome of children who developed tolerance and had received HF as a substitute was similar to that of healthy children, whereas that of children who had not received HF and were either breastfeeding or not consuming any milk was significantly different.
Conclusion: Our results demonstrate that specific gut microbiome signatures are associated with CMA, which differ from those of dietary milk elimination in healthy children. Moreover, HF consumption affects the gut microbiome of children who develop tolerance.

Health Sciences

Gut microbiome, Cow's milk Allergy, Children, Microbial diversity, Hypoallergenic formula

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https://pergamos.lib.uoa.gr/uoa/dl/object/3473982