Κατεύθυνση Νευροεπιστήμες
Library of the School of Science

2025-04-03

2025

Papavranousi-Daponte Danai

Ειρήνη Σκαλιώρα, Καθηγήτρια, Τμήμα Ιστορίας και Φιλοσοφίας της Επιστήμης, ΕΚΠΑ

Object location memory deficits in mice lacking the α5-nicotinic subunit: Effects of sleep, age and sex

English

Object location memory deficits in mice lacking the α5-nicotinic subunit: Effects of sleep, age and sex

Sleep is crucial for memory consolidation, with acetylcholine (ACh) playing a key regulatory role. The α5-nicotinic ACh receptor subunit (α5-nAChR) modulates cholinergic signalling and has been implicated in cognitive functions such as attention, and disorders like schizophrenia. This study investigated the impact of α5-nAChR deletion on object location memory in adolescent and adult mice, considering sex and sleep deprivation effects. Mice lacking the α5-nAChR subunit (ACNA5) showed impaired object location memory, with female ACNA5 mice exhibiting deficits from adolescence onwards, while male ACNA5 mice showed a decline only in adulthood. Sleep deprivation did not affect adolescent mice's memory performance, but impaired it in adult wild-type mice. These findings suggest that the α5-nAChR subunit is essential for object location memory, with age and sex modifying its impact. The study highlights the complex interplay between ACh, sleep, and memory during development, and may have implications for understanding cognitive deficits in neuropsychiatric disorders.

Science

nicotinic receptors, location memory, sleep deprivation, development, females

Yes

2

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120

74

File access is restricted until 2025-10-03.

https://pergamos.lib.uoa.gr/uoa/dl/object/3477329