Ερευνητικό υλικό ΕΚΠΑ

Maternal and perinatal outcomes of pregnant women with SARS-CoV-2 infection

Αγγλικά

Objectives: To evaluate the maternal and perinatal outcomes of pregnancies affected by SARS-CoV-2 infection. Methods: This was a multinational retrospective cohort study including women with a singleton pregnancy and laboratory-confirmed SARS-CoV-2 infection, conducted in 72 centers in 22 different countries in Europe, the USA, South America, Asia and Australia, between 1 February 2020 and 30 April 2020. Confirmed SARS-CoV-2 infection was defined as a positive result on real-time reverse-transcription polymerase chain reaction (RT-PCR) assay of nasopharyngeal swab specimens. The primary outcome was a composite measure of maternal mortality and morbidity, including admission to the intensive care unit (ICU), use of mechanical ventilation and death. Results: In total, 388 women with a singleton pregnancy tested positive for SARS-CoV-2 on RT-PCR of a nasopharyngeal swab and were included in the study. Composite adverse maternal outcome was observed in 47/388 (12.1%) women; 43 (11.1%) women were admitted to the ICU, 36 (9.3%) required mechanical ventilation and three (0.8%) died. Of the 388 women included in the study, 122 (31.4%) were still pregnant at the time of data analysis. Among the other 266 women, six (19.4% of the 31 women with first-trimester infection) had miscarriage, three (1.1%) had termination of pregnancy, six (2.3%) had stillbirth and 251 (94.4%) delivered a liveborn infant. The rate of preterm birth before 37 weeks' gestation was 26.3% (70/266). Of the 251 liveborn infants, 69/251 (27.5%) were admitted to the neonatal ICU, and there were five (2.0%) neonatal deaths. The overall rate of perinatal death was 4.1% (11/266). Only one (1/251, 0.4%) infant, born to a mother who tested positive during the third trimester, was found to be positive for SARS-CoV-2 on RT-PCR. Conclusions: SARS-CoV-2 infection in pregnant women is associated with a 0.8% rate of maternal mortality, but an 11.1% rate of admission to the ICU. The risk of vertical transmission seems to be negligible. © 2020 International Society of Ultrasound in Obstetrics and Gynecology. © 2020 International Society of Ultrasound in Obstetrics and Gynecology

2021

Saccone, G.
Sen, C.
Di Mascio, D.
Galindo, A.
Grünebaum, A.
Yoshimatsu, J.
Stanojevic, M.
Kurjak, A.
Chervenak, F.
Suárez, M.J.R.
Gambacorti-Passerini, Z.M.
de los Angeles Anaya Baz, M.
Galán, E.V.A.
López, Y.C.
Luis, J.A.D.L.
Hernández, I.C.
Herraiz, I.
Villalain, C.
Venturella, R.
Rizzo, G.
Mappa, I.
Gerosolima, G.
Hellmeyer, L.
Königbauer, J.
Ameli, G.
Frusca, T.
Volpe, N.
Schera, G.B.L.
Fieni, S.
Esposito, E.
Simonazzi, G.
Di Donna, G.
Youssef, A.
Gatta, A.N.D.
Di Donna, M.C.
Chiantera, V.
Buono, N.
Sozzi, G.
Greco, P.
Morano, D.
Bianchi, B.
Marino, M.G.L.
Laraud, F.
Ramone, A.
Cagnacci, A.
Barra, F.
Gustavino, C.
Ferrero, S.
Ghezzi, F.
Cromi, A.
Laganà, A.S.
Longo, V.L.
Stollagli, F.
Sirico, A.
Lanzone, A.
Driul, L.
Cecchini, F.
Xodo, S.
Rodriguez, B.
Mercado-Olivares, F.
Elkafrawi, D.
Sisti, G.
Esposito, R.
Coviello, A.
Cerbone, M.
Morlando, M.
Schiattarella, A.
Colacurci, N.
De Franciscis, P.
Cataneo, I.
Lenzi, M.
Sandri, F.
Buscemi, R.
Gattei, G.
Sala, F.D.
Valori, E.
Rovellotti, M.C.
Done, E.
Faron, G.
Gucciardo, L.
Esposito, V.
Vena, F.
Giancotti, A.
Brunelli, R.
Muzii, L.
Nappi, L.
Sorrentino, F.
Liberati, M.
Buca, D.
Leombroni, M.
Di Sebastiano, F.
Franchi, M.
Ianniciello, Q.C.
Garzon, S.
Petriglia, G.
Borrello, L.
Nieto-Calvache, A.J.
Burgos-Luna, J.M.
Kadji, C.
Carlin, A.
Bevilacqua, E.
Moucho, M.
Viana Pinto, P.
Figueiredo, R.
Morales Roselló, J.
Loscalzo, G.
Martinez-Varea, A.
Diago, V.
Jimenez Lopez, J.S.
Aykanat, A.Y.
Cosma, S.
Carosso, A.
Benedetto, C.
Bermejo, A.
Feuerschuette, O.H.M.
Uyaniklar, O.
Ocakouglu, S.R.
Atak, Z.
Gündüz, R.
Haberal, E.T.
Froessler, B.
Parange, A.
Palm, P.
Samardjiski, I.
Taccaliti, C.
Okuyan, E.
Daskalakis, G.
de Sa, R.A.M.
Pittaro, A.
Gonzalez-Duran, M.L.
Guisan, A.C.
Genç, S.Ö.
Zlatohlávková, B.
Piqueras, A.L.
Oliva, D.E.
Cil, A.P.
Api, O.
Antsaklis, P.
Ples, L.
Kyvernitakis, I.
Maul, H.
Malan, M.
Lila, A.
Granese, R.
Ercoli, A.
Zoccali, G.
Villasco, A.
Biglia, N.
Madalina, C.
Costa, E.
Daelemans, C.
Pintiaux, A.
Cueto, E.
Hadar, E.
Dollinger, S.
Brzezinski-Sinai, N.A.
Huertas, E.
Arango, P.
Sanchez, A.
Schvartzman, J.A.
Cojocaru, L.
Turan, S.
Turan, O.
Di Dedda, M.C.
Molpeceres, R.G.
Zdjelar, S.
Premru-Srsen, T.
Kornhauser-Cerar, L.
Druškovic, M.
De Robertis, V.
Stefanovic, V.
Nupponen, I.
Nelskylä, K.
Khodjaeva, Z.
Gorina, K.A.
Sukhikh, G.T.
Maruotti, G.M.
Visentin, S.
Cosmi, E.
Ferrari, J.
Gatti, A.
Luvero, D.
Angioli, R.
Puri, L.
Palumbo, M.
D'Urso, G.
Colaleo, F.
Rapisarda, A.M.C.
Carbone, I.F.
Manzoli, L.
Flacco, M.E.
Nazzaro, G.
Locci, M.
Guida, M.
Sardo, A.D.S.
Panici, P.B.
Khalil, A.
Berghella, V.
Bifulco, G.
Scambia, G.
Zullo, F.
D'Antonio, F.
The WAPM (World Association of Perinatal Medicine) Working Group on COVID-19

Ultrasound in Obstetrics and Gynecology

John Wiley and Sons Ltd

57

2

232-241

adult; artificial ventilation; cohort analysis; diagnosis; female; genetics; hospitalization; human; infant; intensive care unit; isolation and purification; maternal mortality; mortality; newborn; pandemic; pregnancy; pregnancy complication; pregnancy outcome; retrospective study; virology, Adult; Cohort Studies; COVID-19; Female; Hospitalization; Humans; Infant; Infant, Newborn; Intensive Care Units; Maternal Mortality; Pandemics; Pregnancy; Pregnancy Complications, Infectious; Pregnancy Outcome; Respiration, Artificial; Retrospective Studies; SARS-CoV-2

https://doi.org/10.1002/uog.23107

10.1002/uog.23107

https://pergamos.lib.uoa.gr/uoa/dl/object/2984918