Τίτλος:
Cerebrospinal fluid BACE1 activity and Saβppβ as biomarker candidates of alzheimer's disease
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background/Aims: The utility of β-site amyloid-β precursor protein (AβPP) cleaving enzyme 1 (BACE1) activity and soluble AβPP β (sAβPPβ) levels in cerebrospinal fluid (CSF) in detecting Alzheimer's disease (AD) is still elusive. Methods: BACE1 activity and sAβPPβ concentration were measured in patients with AD dementia (n = 56) and mild cognitive impairment (MCI) due to AD (n = 76) with abnormal routine AD CSF markers, in patients with MCI with normal CSF markers (n = 39), and in controls without preclinical AD (n = 48). In a subsample with available 18F-fluorodeoxyglucose positron emission tomography (FDG PET) data, ordinal regression models were employed to compare the contribution of BACE1 and sAβPPβ to correct diagnostic classification to that of FDG PET. Results: BACE1 activity was significantly higher in patients with MCI due to AD compared to both controls and patients with MCI with normal CSF markers. sAβPPβ did not differ between any of the studied groups. Interestingly, BACE1 activity was not found to be inferior to FDG PET as predictive covariate in differentiating between the diagnostic groups. Conclusions: Further studies using biomarker-underpinned diagnoses are warranted to shed more light on the potential diagnostic utility of BACE1 activity as AD biomarker candidate in MCI. © 2018 S. Karger AG, Basel. All rights reserved.
Συγγραφείς:
Alexopoulos, P.
Thierjung, N.
Grimmer, T.
Ortner, M.
Economou, P.
Assimakopoulos, K.
Gourzis, P.
Politis, A.
Perneczky, R.
Περιοδικό:
Dementia and Geriatric Cognitive Disorders
Λέξεις-κλειδιά:
amyloid beta protein[1-42]; amyloid precursor protein; apolipoprotein E4; beta secretase 1; biological marker; fluorodeoxyglucose f 18; tau protein; amyloid precursor protein; aspartic proteinase; BACE1 protein, human; biological marker; fluorodeoxyglucose f 18; radiopharmaceutical agent; secretase, aged; Alzheimer disease; Article; cerebrospinal fluid; controlled study; diagnosis related group; enzyme activity; female; human; major clinical study; male; mild cognitive impairment; Mini Mental State Examination; positron emission tomography; priority journal; Alzheimer disease; cognitive defect; differential diagnosis; middle aged; procedures, Aged; Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Biomarkers; Cognitive Dysfunction; Diagnosis, Differential; Female; Fluorodeoxyglucose F18; Humans; Male; Middle Aged; Positron-Emission Tomography; Radiopharmaceuticals
