Τίτλος:
Mastocytosis with skin manifestations: current status
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Aim To review our present knowledge about mastocyte origin, mastocytosis
classification and management.
Methods Literature review.
Results Mastocytoses are chronic and recurrent disorders with symptoms
which might either be Limited only to the skin or to internal organs as
well. The mastocytes, coming from bone marrow progenitor cells, migrate
to tissues where they participate in inflammation and in cellular
immunity as well as in the metabolism of connective and osseous tissues.
Their proliferation causes the appearance of mastocytoses. The
classification of the clinical manifestations of the mastocytoses into
cutaneous, reactive (under the influence of the degranulator factors)
and systemic disease, facilitates dialog among clinicians. Determination
of prognosis and appropriate therapeutic regimens depend on individual
features.
Conclusions Mastocytosis diagnosis is verified by histological study of
skin lesion biopsy material. Management is symptomatic and unfortunately
does not eradicate the disease. (C) 1999 Elsevier Science B.V. All
rights reserved.
Συγγραφείς:
Katsambas, AD
Karpouzis, AJ
Koumantaki-Mathioudaki, E and
Jorizzo, JL
Περιοδικό:
Journal of the European Academy of Dermatology and Venereology
Λέξεις-κλειδιά:
mastocytosis; mast cell
DOI:
10.1111/j.1468-3083.1999.tb00878.x
