Τίτλος:
Intracerebroventricular endothelin receptor-a blockade in rats decreases phase-II ventricular tachyarrhythmias during acute myocardial infarction
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Endothelin alters central sympathetic responses, but the resultant effects on arrhythmogenesis are unknown. We examined ventricular tachyarrhythmias after endothelin receptor-A blockade in the brain of Wistar rats with acute myocardial infarction. For this aim, BQ-123 (n=6) or phosphate-buffered saline (n=6) were injected intracerebroventricularly. After 10 min, the left coronary artery was ligated, followed by implantation of telemetry transmitters. Electrocardiography and voluntary activity (as a surrogate of acute left ventricular failure) were continuously monitored for 24 h. Infarct-size was similar in the two groups. There were fewer episodes of ventricular tachyarrhythmias of shorter average duration in treated rats, leading to markedly shorter total duration (12.3±8.9 s), when compared to controls (546.2±130.3 s). Voluntary activity increased in treated rats during the last hours of recording, but bradyarrhythmic episodes were comparable between the two groups. Endothelin receptor-A blockade in the brain of rats decreases the incidence of ventricular tachyarrhythmias post-ligation, without affecting bradyarrhythmic episodes. These findings call for further research on the pathophysiologic role of endothelin during acute myocardial infarction. © 2019 Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic.
Συγγραφείς:
Lekkas, P.
Georgiou, E.S.
Kontonika, M.
Mouchtouri, E.-T.
Mourouzis, I.
Pantos, C.
Kolettis, T.M.
Περιοδικό:
Physiological Research
Εκδότης:
Czech Academy of Sciences
Λέξεις-κλειδιά:
cyclo(Trp-Asp-Pro-Val-Leu); cyclopeptide; endothelin A receptor; endothelin A receptor antagonist, animal; brain ventricle; complication; disease model; drug effect; heart infarction; heart ventricle extrasystole; heart ventricle tachycardia; intracerebroventricular drug administration; metabolism; pathophysiology; Wistar rat, Animals; Cerebral Ventricles; Disease Models, Animal; Endothelin A Receptor Antagonists; Injections, Intraventricular; Myocardial Infarction; Peptides, Cyclic; Rats, Wistar; Receptor, Endothelin A; Tachycardia, Ventricular; Ventricular Premature Complexes
DOI:
10.33549/physiolres.934135
