Τίτλος:
Randomized controlled trial of intravenous immunoglobulin versus oral
prednisolone in chronic inflammatory demyelinating
polyradiculoneuropathy
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
This multicenter, randomized, double-blind, crossover trial compared a
six week course of oral prednisolone tapering from 60 mg to 10 mg daily
with intravenous immunoglobulin (IVIg) 2.0 g/kg given over one to two
days for treating chronic inflammatory demyelinating
polyradiculoneuropathy (CIDP). Twenty-four of the thirty-two randomized
patients completed both treatment periods. Both treatments produced
significant improvements in the primary outcome measure, change in an
11-point disability scale two weeks after randomization. There was
slightly, but not significantly, more improvement after Mg than with
prednisolone, the mean difference between the groups in change in
disability grade being 0.16 (95% CI = -0.35 to 0.66). There were also
slightly, but not significantly, greater improvements favoring Mg in the
secondary outcome measures: time to walk 10 meters after two weeks and
improvement in disability grade after six weeks. Results may have been
biased against Mg by the eight patients who did not complete the second
arm of the trial. A serious adverse event (psychosis) attributable to
treatment occurred in one patient while on prednisolone and in none with
Mg.
Συγγραφείς:
Hughes, R
Bensa, S
Willison, H
Van den Bergh, P
Comi, G
and Illa, I
Nobile-Orazio, E
van Doorn, P
Dalakas, M and
Bojar, M
Swan, A
INCAT Grp
Περιοδικό:
Annals of Neurology
Εκδότης:
Wiley-Liss, Inc.
