Περίληψη:
Purpose: Longitudinal data on the effect of time and environmental conditions on physical activity (PA) among COPD patients are currently scarce, but this is an important factor in the design of trials to test interventions that might impact on it. Thus, we aimed to assess the effect of time and climate conditions (temperature, day length and rainfall) on progression of PA in a cohort of COPD patients. Patients and methods: This is a prospective, multicenter, cohort study undertaken as part of the EU/IMI PROactive project, in which we assessed 236 COPD patients simultaneously wearing two activity monitors (Dynaport MiniMod and Actigraph GT3X). A multivariable generalized linear model analysis was conducted to describe the effect of the explanatory variables on PA measures, over three time points (baseline, 6 and 12 months). Results: At 12 months (n=157; FEV1% predicted=57.7±21.9) there was a significant reduction in all PA measures (Actigraph step count (4284±3533 vs 3533±293)), Actigraph moderate- to vigorous-intensity PA ratio (8.8 (18.8) vs 6.1 (15.7)), Actigraph vector magnitude units (374,902.4 (265,269) vs 336,240 (214,432)), MiniMod walking time (59.1 (34.9) vs 56.9 (38.7) mins) and MiniMod PA intensity (0.183 (0) vs 0.181 (0)). Time had a significant, negative effect on most PA measures in multivariable analysis, after correcting for climate factors, study center, age, FEV1% predicted, 6MWD and other disease severity measures. Rainfall was the only climate factor with a negative effect on most PA parameters. Conclusion: COPD patients demonstrate a significant decrease in PA over 1 year follow-up, which is further affected by hours of rainfall, but not by other climate considerations. © 2019 Boutou et al.
Συγγραφείς:
Boutou, A.K.
Raste, Y.
Demeyer, H.
Troosters, T.
Polkey, M.I.
Vogiatzis, I.
Louvaris, Z.
Rabinovich, R.A.
Van Der Molen, T.
Garcia-Aymerich, J.
Hopkinson, N.S.
Λέξεις-κλειδιά:
rain, actimetry; aged; Article; chronic obstructive lung disease; climate; cohort analysis; controlled study; day length; disease exacerbation; female; high risk population; human; major clinical study; male; multicenter study; physical inactivity; prospective study; risk assessment; risk factor; temperature sensitivity; time; total lung capacity; walking parameters; walking time; activity tracker; chronic obstructive lung disease; clinical trial; disease exacerbation; exercise tolerance; follow up; lung function test; middle aged; pathophysiology; physiology; time factor; walking, Aged; Climate; Disease Progression; Exercise Tolerance; Female; Fitness Trackers; Follow-Up Studies; Humans; Male; Middle Aged; Prospective Studies; Pulmonary Disease, Chronic Obstructive; Respiratory Function Tests; Sedentary Behavior; Time Factors; Walking
