Τίτλος:
The significance of survivin and nectin-4 expression in the prognosis of breast carcinoma
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
To investigate the prognostic significance of Survivin and Nectin-4 expression in breast carcinomas. Imprint smears were obtained from 140 breast carcinoma specimens and studied immunocytochemically for the expression of Survivin and Nectin-4. The results were correlated with several clinicopathological parameters, including five-year survival. Increased Survivin staining pattern correlated with increased grade (p< 0.0001), increased lymph node invasion (p< 0.0001), increased tumor size and reduced survival (p< 0.0001). Elevated Nectin-4 expression also correlated significantly with increased grade (p< 0.0001), increased tumor size (p< 0.0001) and reduced survival (p< 0.0001). In addition, Survivin and Nectin-4 staining patterns correlated strongly with one another (p< 0.0001). However, on multivariate analysis, neither Survivin nor Nectin-4 expression seemed to have an independent impact on survival in our study cases. The findings of our study suggest that increased expression of Survivin and Nectin-4 may indicate a worse prognosis in breast cancer patients. The exact implications of the expression of these markers in breast cancer prognosis and treatment remain to be clarified. © Polish Society for Histochemistry and Cytochemistry.
Συγγραφείς:
Athanassiadou, A.M.
Patsouris, E.
Tsipis, A.
Gonidi, M.
Athanassiadou, P.
Περιοδικό:
Folia Histochemica et Cytobiologica
Εκδότης:
Via Medica SP Zoo
Λέξεις-κλειδιά:
antiestrogen; cell adhesion molecule; cyclophosphamide; doxorubicin; nectin 4; paclitaxel; survivin; unclassified drug, adult; aged; article; breast carcinoma; breast surgery; cancer grading; cancer patient; cancer size; cancer survival; controlled study; female; histopathology; human; human tissue; immunocytochemistry; lymph node metastasis; major clinical study; multiple cycle treatment; prognosis; protein analysis; protein expression; smear; survival time
DOI:
10.5603/FHC.2011.0005
