Τίτλος:
Primary aldosteronism: Novel insights
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: Primary aldosteronism is one of the most common causes of secondary hypertension. Patients with this endocrine syndrome are at increased cardiovascular risk, higher than hypertensive individuals with equal blood pressure levels. Objectives: The study aimed to thoroughly present and critically discuss the novel insights into the field of primary aldosteronism, focusing on the clinically meaningful aspects. Method: We meticulously evaluated existing data in the field of primary aldosteronism in order to summarize future perspectives in this narrative review. Results: Novel data suggests that a subclinical form of primary aldosteronism might exist. Interesting findings might simplify the diagnostic procedure of the disease, especially for the localization of primary aldosteronism. The most promising progress has been noted in the field of the molecular basis of the disease, suggesting new potential therapeutic targets. Conclusion: Several significant aspects are at early stages of evaluation. Future research is essential to investigate these well-promising perspectives. © 2020 Bentham Science Publishers.
Συγγραφείς:
Stavropoulos, K.
Imprialos, K.
Papademetriou, V.
Faselis, C.
Tsioufis, K.
Dimitriadis, K.
Doumas, M.
Περιοδικό:
Current Hypertension Reviews
Εκδότης:
Bentham Science Publishers
Λέξεις-κλειδιά:
CD56 antigen; mineralocorticoid antagonist; mineralocorticoid receptor; renin; antihypertensive agent, adrenal gland; adrenal incidentaloma; adrenalectomy; aldosterone blood level; blood pressure; cardiovascular risk; cell isolation; computer assisted tomography; cytokine release; diagnostic accuracy; enzyme activity; genetic transfection; heart left ventricle hypertrophy; human; image analysis; nuclear magnetic resonance imaging; plasma renin activity; positron emission tomography; prevalence; primary hyperaldosteronism; priority journal; Review; treadmill exercise; drug effect; hyperaldosteronism; hypertension; pathophysiology; risk factor; treatment outcome, Antihypertensive Agents; Blood Pressure; Humans; Hyperaldosteronism; Hypertension; Risk Factors; Treatment Outcome
DOI:
10.2174/1573402115666190415155512
